Exploration of novel phthalazinone derivatives as potential efflux transporter inhibitors for reversing multidrug resistance and improving the oral absorption of paclitaxel.
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DOI: 10.1016/j.ejmech.2022.114231
Abstract: Chemotherapy is an important means of cancer treatment. However, overexpression of efflux transporters (including but not limited to P-gp and BCRP) can lead to resistance to cancer chemotherapy. Multiple-target inhibitors of efflux transporter can be… read more here.
Keywords: efflux transporter; resistance; absorption paclitaxel; efflux ... See more keywords