Apatinib enhances chemosensitivity of ABT‐199 in diffuse large B‐cell lymphoma
Sign Up to like & getrecommendations! Published in 2022 at "Molecular Oncology"
DOI: 10.1002/1878-0261.13309
Abstract: To investigate the effect of Apatinib (an inhibitor targeting VEGFR‐2) enhances chemosensitivity of ABT‐199 on diffuse large B‐cell lymphoma (DLBCL). Viability assay and flow cytometric assay for determining apoptosis, cell cycle, mitochondrial membrane potential, reactive… read more here.
Keywords: cell; abt 199; dlbcl; enhances chemosensitivity ... See more keywords
BH3 Mimetic ABT-199 Enhances the Sensitivity of Gemcitabine in Pancreatic Cancer in vitro and in vivo
Sign Up to like & getrecommendations! Published in 2018 at "Digestive Diseases and Sciences"
DOI: 10.1007/s10620-018-5253-7
Abstract: Background and AimsPancreatic cancer is an aggressive malignancy with poor prognosis. Gemcitabine is the standard chemotherapeutic drug used to treat the disease; however, it has a low response rate. Therefore, there is an urgent need… read more here.
Keywords: abt 199; gemcitabine; pancreatic cancer; sensitivity ... See more keywords
Glycine ameliorates mitochondrial dysfunction caused by ABT-199 in porcine oocytes.
Sign Up to like & getrecommendations! Published in 2021 at "Journal of animal science"
DOI: 10.1093/jas/skab072
Abstract: Mitochondria play an important role in controlling oocyte developmental competence. Our previous studies showed that glycine can regulate mitochondrial function and improve oocyte maturation in vitro. However, the mechanisms by which glycine affects mitochondrial function… read more here.
Keywords: abt 199; porcine oocytes; oocyte maturation; mitochondrial dysfunction ... See more keywords
SUCCESSFUL INDUCTION OF HEMATOPOIETIC CHIMERISM BY MCL-1 AND BCL-2 INHIBITION WITHOUT RADIATION/CHEMO THERAPY IN NONHUMAN PRIMATES
Sign Up to like & getrecommendations! Published in 2020 at "Transplantation"
DOI: 10.1097/01.tp.0000699448.79133.8d
Abstract: Allograft tolerance in clinical HLA mismatched kidney transplantation has been achieved by induction of hematopoietic chimerism via donor bone marrow transplantation (BMT). However, wider clinical application of tolerance regimens has been hampered by the myelosuppressive… read more here.
Keywords: mcl; abt 199; chimerism; hematopoietic chimerism ... See more keywords
Treatment with bortezomib in dense deposit disease associated with monoclonal gammopathy of undetermined significance
Sign Up to like & getrecommendations! Published in 2019 at "British Journal of Haematology"
DOI: 10.1111/bjh.15081
Abstract: Ibrutinib treatment for 72 hours at 5 doses in MCL lines, IR, ibrutinib resistance. IC50s were calculated using GraphPad Prism software. (B) CCK8 assay showing the effects of ABT199, AZD8055 and the combination of ABT-199… read more here.
Keywords: abt 199; ibrutinib; treatment; combination abt ... See more keywords
Doxorubicin and ABT-199 Coencapsulated Nanocarriers for Targeted Delivery and Synergistic Treatment against Hepatocellular Carcinoma
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Nanomaterials"
DOI: 10.1155/2019/5274598
Abstract: For the patients with hepatocellular carcinoma (HCC), conventional chemotherapy is insufficient or has no benefit. Although combination chemotherapy has been proven as an efficient strategy to enhance anti-HCC efficacy, some barriers, such as low bioavailability… read more here.
Keywords: hepatocellular carcinoma; abt 199; hcc; dds nps ... See more keywords
Genetic Characterization of ABT-199 Sensitivity in Human AML
Sign Up to like & getrecommendations! Published in 2018 at "Blood"
DOI: 10.1182/blood-2018-99-113062
Abstract: Acute myeloid leukemias (AML) are aggressive blood cancers characterized by an overall survival of 27% at 5 years. The main challenge in AML treatment originates from the genetic heterogeneity of the disease that contributes to… read more here.
Keywords: treatment; abt 199; aml; 199 sensitivity ... See more keywords
NOTCH2 Contributes to Venetoclax Resistance in Chronic Lymphocytic Leukemia
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DOI: 10.1182/blood-2019-128499
Abstract: BACKGROUND: Chronic lymphocytic leukemia (CLL) has recently experienced an unprecedented revolution thanks to the discovery of crucial pathogenetic mechanisms. Despite considerable therapeutic advancements, the eradication of the disease is not complete and resistance and transformation… read more here.
Keywords: abt 199; response; resistance; expression ... See more keywords
All-Trans Retinoic Acid Enhances the Anti-Leukemia Effect of Venetoclax on Acute Myeloid Leukemia Cells
Sign Up to like & getrecommendations! Published in 2019 at "Blood"
DOI: 10.1182/blood-2019-128551
Abstract: Objective: Acute myeloid leukemia (AML) is a malignant disease of the hematopoietic system in which arrested maturation, excessive proliferation and inhibition of apoptosis have been observed in the process of hematopoietic stem cell differentiation. Some… read more here.
Keywords: abt 199; group; expression; leukemia ... See more keywords
Identification of a New Targeted Therapy for T-Cell Acute Lymphoblastic Leukemia and Studies on Its Mechanism of Action
Sign Up to like & getrecommendations! Published in 2019 at "Blood"
DOI: 10.1182/blood-2019-129823
Abstract: Background: Acute lymphoblastic leukemia (ALL) is the most frequent pediatric malignancy, of which T- cell acute lymphoblastic leukemia (T-ALL) constitutes an aggressive subset. Due to the advent of new therapies, T-ALL now has a 5-year… read more here.
Keywords: abt 199; plk1; cell lines; bcl ... See more keywords
Mcl-1 expression and JNK activation induces a threshold for apoptosis in Bcl-xL-overexpressing hematopoietic cells
Sign Up to like & getrecommendations! Published in 2017 at "Oncotarget"
DOI: 10.18632/oncotarget.14223
Abstract: The regulation of Mcl-1 expression is necessary for the induction of cancer cell apoptosis by ABTs such as ABT-737, ABT-263 and ABT-199. However, the reduction in Mcl-1 expression is not sufficient for initiating cell death… read more here.
Keywords: abt 199; apoptosis; mcl expression; jnk activation ... See more keywords