Abundance of conserved CRISPR-Cas9 target sites within the highly polymorphic genomes of Anopheles and Aedes mosquitoes
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DOI: 10.1038/s41467-020-15204-0
Abstract: A number of recent papers report that standing genetic variation in natural populations includes ubiquitous polymorphisms within target sites for Cas9-based gene drive (CGD) and that these “drive resistant alleles” (DRA) preclude the successful application… read more here.
Keywords: target sites; target; natural populations; genetic variation ... See more keywords