Massively parallel characterization of CYP2C9 variant enzyme activity and abundance.
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DOI: 10.1016/j.ajhg.2021.07.001
Abstract: CYP2C9 encodes a cytochrome P450 enzyme responsible for metabolizing up to 15% of small molecule drugs, and CYP2C9 variants can alter the safety and efficacy of these therapeutics. In particular, the anti-coagulant warfarin is prescribed… read more here.
Keywords: cyp2c9; massively parallel; abundance massively; enzyme ... See more keywords