Digging More Missing Proteins Using an Enrichment Approach with ProteoMiner.
Sign Up to like & getrecommendations! Published in 2017 at "Journal of proteome research"
DOI: 10.1021/acs.jproteome.7b00353
Abstract: Human Proteome Project (HPP) aims at mapping entire human proteins with a systematic effort upon all the emerging techniques, which would enhance understanding of human biology and lay a foundation for development of medical applications.… read more here.
Keywords: digging missing; missing proteins; abundance proteins; unique peptides ... See more keywords
Nanoproteomics enables proteoform-resolved analysis of low-abundance proteins in human serum
Sign Up to like & getrecommendations! Published in 2020 at "Nature Communications"
DOI: 10.1038/s41467-020-17643-1
Abstract: Top-down mass spectrometry (MS)-based proteomics provides a comprehensive analysis of proteoforms to achieve a proteome-wide understanding of protein functions. However, the MS detection of low-abundance proteins from blood remains an unsolved challenge due to the… read more here.
Keywords: abundance proteins; analysis; proteoform resolved; human serum ... See more keywords
Plasma/serum proteomics: depletion strategies for reducing high-abundance proteins for biomarker discovery.
Sign Up to like & getrecommendations! Published in 2019 at "Bioanalysis"
DOI: 10.4155/bio-2019-0145
Abstract: Plasma and serum are widely used for proteomics-based biomarker discovery. However, analysis of these biofluids is highly challenging due to the complexity and wide dynamic range of their proteomes. Notably, highly abundant proteins tend to… read more here.
Keywords: biomarker discovery; abundance proteins; serum; depletion ... See more keywords