Computational Model Reveals Limited Correlation between Germinal Center B-Cell Subclone Abundancy and Affinity: Implications for Repertoire Sequencing
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DOI: 10.3389/fimmu.2017.00221
Abstract: Immunoglobulin repertoire sequencing has successfully been applied to identify expanded antigen-activated B-cell clones that play a role in the pathogenesis of immune disorders. One challenge is the selection of the Ag-specific B cells from the… read more here.
Keywords: subclone; abundancy affinity; affinity; repertoire sequencing ... See more keywords