Extended Release Pellets Prepared by Hot Melt Extrusion Technique for Abuse Deterrent Potential: Category-1 In-vitro Evaluation.
Sign Up to like & getrecommendations! Published in 2020 at "International journal of pharmaceutics"
DOI: 10.1016/j.ijpharm.2020.119624
Abstract: The objective of the present study was to develop extended-release (ER) hot-melt extruded (HME) abuse-deterrent pellets of acetaminophen, a model drug, by utilizing high molecular weight polyethylene oxide (PEO) and gelling agents (xanthan gum, guar… read more here.
Keywords: extended release; abuse deterrent; hot melt; abuse ... See more keywords
Mitigation of IV Abuse Through the Use of Abuse‐Deterrent Opioid Formulations: An Overview of Current Technologies
Sign Up to like & getrecommendations! Published in 2019 at "Pain Practice"
DOI: 10.1111/papr.12760
Abstract: Providers who treat patients with chronic pain face a dual challenge: providing adequate access to opioid therapies for appropriate pain management while adopting strategies to minimize the risk for abuse. Commonly prescribed opioids have substantial… read more here.
Keywords: use; abuse deterrent; opioid abuse; abuse ... See more keywords
Effect of Manufacturing Process on the Retention of Abuse-Deterrent Properties of PEO-Matrix Tablets.
Sign Up to like & getrecommendations! Published in 2021 at "AAPS PharmSciTech"
DOI: 10.1208/s12249-021-02169-6
Abstract: Polyethylene oxide (PEO) is a widely used polymer in the development of abuse-deterrent oral formulations. Different manufacturing processes including direct compression (DC) followed by sintering, wet granulation (WG) followed by compression and sintering, and hot… read more here.
Keywords: abuse deterrent; retention abuse; drug;
Abuse-deterrent opioid analgesics: a guide for clinicians.
Sign Up to like & getrecommendations! Published in 2020 at "Pain management"
DOI: 10.2217/pmt-2019-0052
Abstract: The US FDA has encouraged the development of abuse-deterrent formulations (ADFs) of opioid analgesics as one component in a comprehensive effort to combat prescription opioid abuse. Guidance issued by the FDA outlines three types of… read more here.
Keywords: guide clinicians; analgesics guide; abuse deterrent; opioid analgesics ... See more keywords
Insights and issues from FDA Advisory Committee meetings on abuse-deterrent opioids.
Sign Up to like & getrecommendations! Published in 2017 at "Journal of opioid management"
DOI: 10.5055/jom.2017.0416
Abstract: It is the current policy of the US Food and Drug Administration (FDA) to convene expert Advisory Committees to provide input on key regulatory decisions regarding opioid products, including approval and labeling of opioid abuse-deterrent… read more here.
Keywords: advisory committee; advisory committees; abuse deterrent; committee meetings ... See more keywords
Interpreting labels of abuse-deterrent opioid analgesics.
Sign Up to like & getrecommendations! Published in 2017 at "Journal of opioid management"
DOI: 10.5055/jom.2017.0418
Abstract: OBJECTIVE To provide an overview of available abuse-deterrent opioids (ADOs) and the labeling text that describes abuse-deterrent (AD) properties. DESIGN A nonsystematic review of ADO literature and regulatory documents guiding their development. OUTCOME MEASURES/RESULTS A… read more here.
Keywords: abuse deterrent; interpreting labels; opioid analgesics; deterrent opioid ... See more keywords