Oral cannabidiol does not produce a signal for abuse liability in frequent marijuana smokers.
Sign Up to like & getrecommendations! Published in 2017 at "Drug and alcohol dependence"
DOI: 10.1016/j.drugalcdep.2016.11.030
Abstract: BACKGROUND Cannabidiol (CBD) is a naturally occurring constituent of the marijuana plant. In the past few years, there has been great interest in the therapeutic effects of isolated CBD and it is currently being explored… read more here.
Keywords: marijuana; abuse liability; cannabidiol; oral cannabidiol ... See more keywords
Similar precipitated withdrawal effects on intracranial self-stimulation during chronic infusion of an e-cigarette liquid or nicotine alone
Sign Up to like & getrecommendations! Published in 2017 at "Pharmacology Biochemistry and Behavior"
DOI: 10.1016/j.pbb.2017.08.011
Abstract: ABSTRACT The FDA recently extended their regulatory authority to electronic cigarettes (ECs). Because the abuse liability of ECs is a leading concern of the FDA, animal models are urgently needed to identify factors that influence… read more here.
Keywords: abuse liability; nicotine alone; chronic infusion; withdrawal ... See more keywords
OREX-1038: a potential new treatment for pain with low abuse liability and limited adverse effects
Sign Up to like & getrecommendations! Published in 2022 at "Behavioural Pharmacology"
DOI: 10.1097/fbp.0000000000000684
Abstract: Drugs targeting mu opioid receptors are the mainstay of clinical practice for treating moderate-to-severe pain. While they can offer excellent analgesia, their use can be limited by adverse effects, including constipation, respiratory depression, tolerance, and… read more here.
Keywords: orex 1038; adverse effects; pain; limited adverse ... See more keywords
Recommendations for the Use of Behavioral Economic Demand as an Abuse Liability Assessment for Drug Scheduling
Sign Up to like & getrecommendations! Published in 2023 at "Policy Insights from the Behavioral and Brain Sciences"
DOI: 10.1177/23727322221150197
Abstract: Before being marketed in the United States, novel drugs must undergo evaluation for abuse liability. Drugs with higher abuse liability are assigned a schedule associated with stricter regulatory controls. Behavioral economic demand techniques hold great… read more here.
Keywords: liability; economic demand; abuse liability; behavioral economic ... See more keywords
Cigarette Smoke Extract, but Not Electronic Cigarette Aerosol Extract, Inhibits Monoamine Oxidase in vitro and Produces Greater Acute Aversive/Anhedonic Effects Than Nicotine Alone on Intracranial Self-Stimulation in Rats
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Neuroscience"
DOI: 10.3389/fnins.2022.868088
Abstract: Conventional tobacco cigarettes appear to have greater abuse liability than non-combusted products such as electronic cigarettes (ECs) and nicotine replacement therapy (NRT). This may be due to the higher levels of behaviorally active non-nicotine constituents… read more here.
Keywords: nicotine alone; abuse liability; aversive anhedonic;
Abuse Liability of Baclofen
Sign Up to like & getrecommendations! Published in 2018 at "Clinical Psychopharmacology and Neuroscience"
DOI: 10.9758/cpn.2018.16.1.126
Abstract: TO THE EDITOR I read with interest the case report on baclofen abuse by Ghosh and Bhuyan in May issue of Clinincal Psychopharmacology and Neuroscience 2017. The patient reportedly was prescribed quetiapine 100 mg, escitalopram… read more here.
Keywords: baclofen; abuse liability; euphorient effects; baclofen abuse ... See more keywords