Decoding the Structure of Abuse Potential for New Psychoactive Substances: Structure-Activity Relationships for Abuse-Related Effects of 4-Substituted Methcathinone Analogs.
Sign Up to like & getrecommendations! Published in 2017 at "Current topics in behavioral neurosciences"
DOI: 10.1007/7854_2016_18
Abstract: Many cathinone analogs act as substrates or inhibitors at dopamine, norepinephrine, and serotonin transporters (DAT, NET, SERT, respectively). Drug selectivity at DAT vs. SERT is a key determinant of abuse potential for monoamine transporter substrates… read more here.
Keywords: dat sert; substituted methcathinone; structure activity; structure ... See more keywords
The Abuse Potential of Prescription Opioids in Humans-Closing in on the First Century of Research.
Sign Up to like & getrecommendations! Published in 2017 at "Current topics in behavioral neurosciences"
DOI: 10.1007/7854_2016_448
Abstract: While opioids are very effective analgesics for treating acute pain, humans have struggled with opiate addiction for millenia. An opium abuse epidemic in the early 1900's led the US government to develop a systematic research… read more here.
Keywords: potential prescription; prescription opioids; research; abuse potential ... See more keywords
Relationships heal: Reducing harsh parenting and child abuse potential with relationship-based parent-infant home visiting
Sign Up to like & getrecommendations! Published in 2021 at "Children and Youth Services Review"
DOI: 10.1016/j.childyouth.2021.106135
Abstract: Abstract Background Childhood maltreatment and harsh parenting can have lasting effects on young children’s development, and home visiting interventions provide critical opportunities to mitigate this risk. Objective This study aimed to examine associations between participation… read more here.
Keywords: harsh parenting; abuse potential; home visiting; child abuse ... See more keywords
Preclinical assessment of the abuse potential of the orexin receptor antagonist, suvorexant
Sign Up to like & getrecommendations! Published in 2017 at "Regulatory Toxicology and Pharmacology"
DOI: 10.1016/j.yrtph.2017.03.006
Abstract: &NA; Suvorexant (Belsomra®) is a dual orexin receptor antagonist approved for the treatment of insomnia. Because of its pharmacology within the central nervous system, intended therapeutic indication, and first‐in‐class status, an assessment of suvorexant abuse… read more here.
Keywords: suvorexant; receptor antagonist; pharmacology; assessment ... See more keywords
5 Clinical Evaluation of the Abuse Potential of Buprenorphine/Samidorphan Combination
Sign Up to like & getrecommendations! Published in 2019 at "CNS Spectrums"
DOI: 10.1017/s1092852919000038
Abstract: Abstract Introduction Buprenorphine (BUP)/samidorphan (SAM) combination is an opioid system modulator being investigated as an adjunctive treatment for major depressive disorder (MDD). BUP/SAM is a fixed-dose combination of BUP, a partial µ-opioid receptor agonist and… read more here.
Keywords: bup; combination; drug liking; abuse potential ... See more keywords
0500 Evaluation of the Human Abuse Potential of Single Oral Doses of V117957, a Novel, Highly Potent and Selective Partial Agonist for Nociceptin/Orphanin-FQ Peptide (NOP) Receptors
Sign Up to like & getrecommendations! Published in 2020 at "Sleep"
DOI: 10.1093/sleep/zsaa056.497
Abstract: The satisfactory safety/tolerability profile of V117957, an investigational NOP receptor partial agonist, has been previously established in ~200 healthy subjects with maximum doses at 30mg following a single oral administration and 10mg once daily for… read more here.
Keywords: abuse potential; v117957 1mg; placebo; partial agonist ... See more keywords
Evaluation of the abuse potential of pitolisant, a selective H3-receptor antagonist/inverse agonist, for the treatment of adult patients with narcolepsy with or without cataplexy
Sign Up to like & getrecommendations! Published in 2019 at "Sleep"
DOI: 10.1093/sleep/zsz252
Abstract: Abstract Objectives To evaluate the human abuse potential of pitolisant, a selective histamine 3 (H3)-receptor antagonist/inverse agonist recently approved by the US Food and Drug Administration for the treatment of excessive daytime sleepiness in adult… read more here.
Keywords: pitolisant; receptor antagonist; pitolisant selective; drug ... See more keywords
Assessment of abuse potential of carfentanil
Sign Up to like & getrecommendations! Published in 2023 at "Addiction Biology"
DOI: 10.1111/adb.13265
Abstract: Carfentanil, as a fentanyl analogue, is a potent synthetic opioid. It has been controlled in many countries, and its emergence has been highlighted by many recent reports. However, although discriminative stimulus effects of carfentanil in… read more here.
Keywords: fentanyl heroin; potential carfentanil; abuse potential; carfentanil fentanyl ... See more keywords
Evaluation of the abuse potential of difelikefalin, a selective kappa-opioid receptor agonist, in recreational polydrug users.
Sign Up to like & getrecommendations! Published in 2021 at "Clinical and translational science"
DOI: 10.1111/cts.13173
Abstract: Difelikefalin, a selective kappa-opioid receptor agonist with limited central nervous system penetration, is being developed for the treatment of chronic pruritic conditions. This randomized, double-blind, active- and placebo-controlled, four-way crossover study was designed to evaluate… read more here.
Keywords: opioid receptor; difelikefalin; receptor agonist; potential difelikefalin ... See more keywords
Epigenetic Neuropharmacology: Drugs Affecting the Epigenome in the Brain.
Sign Up to like & getrecommendations! Published in 2020 at "Annual review of pharmacology and toxicology"
DOI: 10.1146/annurev-pharmtox-030220-022920
Abstract: This review explores how different classes of drugs, including those with therapeutic and abuse potential, alter brain functions and behavior via the epigenome. Epigenetics, in its simplest interpretation, is the study of the regulation of… read more here.
Keywords: epigenetic neuropharmacology; pharmacology; epigenome; brain ... See more keywords
Psychedelic drug abuse potential assessment for new drug applications and controlled substance scheduling: A United States perspective
Sign Up to like & getrecommendations! Published in 2023 at "Journal of Psychopharmacology"
DOI: 10.1177/02698811221140004
Abstract: Background: Psychedelics are an increasingly active area of research and pharmaceutical development. This includes abuse potential assessment to better understand their pharmacological mechanisms and effects and guide controlled substance regulation. Psychedelics pose challenges to abuse… read more here.
Keywords: controlled substance; abuse potential; potential assessment; psychedelic drug ... See more keywords