Antibiotics are associated with attenuated efficacy of anti-PD-1/PD-L1 therapies in Chinese patients with advanced non-small cell lung cancer.
Sign Up to like & getrecommendations! Published in 2019 at "Lung cancer"
DOI: 10.1016/j.lungcan.2019.01.017
Abstract: OBJECTIVES Gut microbiome plays a dominant role in modulating therapeutic efficacy of immune checkpoint inhibitors (ICIs) targeting the programmed cell death receptor/ligand-1 (PD-1/PD-L1) pathway, suggesting that co-administration of antibiotics (Abx), which might result in dysbacteriosis,… read more here.
Keywords: abx; treatment; lung cancer; patients advanced ... See more keywords
Impact of antibiotic treatment during platinum chemotherapy on survival and recurrence in women with advanced epithelial ovarian cancer.
Sign Up to like & getrecommendations! Published in 2020 at "Gynecologic oncology"
DOI: 10.1016/j.ygyno.2020.09.010
Abstract: OBJECTIVE(S) To determine whether antibiotic treatment (ABX) during platinum chemotherapy (PC) for epithelial ovarian cancer (EOC) impacts progression-free survival (PFS) and overall survival (OS). STUDY DESIGN Retrospective single institution cohort study in women with newly… read more here.
Keywords: abx; treatment; platinum chemotherapy; antibiotic treatment ... See more keywords
1773. Impact of Antibiotics Used to Treat Community Acquired Pneumonia on the Gut Microbiome and Resistome in Healthy Volunteers
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DOI: 10.1093/ofid/ofy209.158
Abstract: Abstract Background Antibiotics (ABX) are frequently inappropriately used to treat nonbacterial causes of respiratory illnesses. The goal of this prospective cohort study was to characterize the impact of ABX used to treat community-acquired pneumonia (CAP)… read more here.
Keywords: abx; consulting fee; consultant; used treat ... See more keywords
Th2 and metabolic responses to nematodes are independent of prolonged host microbiota abrogation
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DOI: 10.1111/pim.12957
Abstract: Antibiotic treatment can lead to elimination of both pathogenic bacteria and beneficial commensals, as well as to altered host immune responses. Here, we investigated the influence of prolonged antibiotic treatment (Abx) on effector, memory and… read more here.
Keywords: abx; host microbiota; microbiota abrogation; infection ... See more keywords
Impact of total parenteral nutrition and antibiotics on hepatic and intestinal homeostasis in pediatric murine model
Sign Up to like & getrecommendations! Published in 2023 at "Physiology"
DOI: 10.1152/physiol.2023.38.s1.5663725
Abstract: Parenteral nutrition (PN) prevents starvation and supports metabolic requirements intravenously when patients are unable to feed enterally. Adult rodents and piglets have been used in PN research for decades, while almost no research has used… read more here.
Keywords: abx; physiology; model; parenteral nutrition ... See more keywords
Prophylactic Antibiotic Use and Risk of Meningococcal Infections in Patients with Paroxysmal Nocturnal Hemoglobinuria (PNH) Treated with Eculizumab Who Received Meningococcal Vaccination: Results from the International PNH Registry
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DOI: 10.1182/blood-2019-127005
Abstract: INTRODUCTION Paroxysmal nocturnal hemoglobinuria (PNH) patients treated with eculizumab have an increased susceptibility to serious meningococcal infections. In the largest safety data set to date, representing >10 years of postmarketing pharmacovigilance surveillance of eculizumab for… read more here.
Keywords: abx; meningococcal infection; consultancy honoraria; infection ... See more keywords