Identification of ABX-1431, a Selective Inhibitor of Monoacylglycerol Lipase and Clinical Candidate for Treatment of Neurological Disorders.
Sign Up to like & getrecommendations! Published in 2018 at "Journal of medicinal chemistry"
DOI: 10.1021/acs.jmedchem.8b00951
Abstract: The serine hydrolase monoacylglycerol lipase (MGLL) converts the endogenous cannabinoid receptor agonist 2-arachidonoylglycerol (2-AG) and other monoacylglycerols into fatty acids and glycerol. Genetic or pharmacological inactivation of MGLL leads to elevation in 2-AG in the… read more here.
Keywords: mgll; abx 1431; inhibitor; monoacylglycerol lipase ... See more keywords
The Monoacylglycerol Lipase Inhibitor ABX-1431 Does Not Improve Alcoholic Liver Disease.
Sign Up to like & getrecommendations! Published in 2023 at "Cannabis and cannabinoid research"
DOI: 10.1089/can.2023.0003
Abstract: Introduction: Excessive alcohol consumption can result in alcoholic liver disease (ALD). There is no FDA-approved drug to specifically treat ALD and current management approaches have limited efficacy. Past studies indicate that monoacylglycerol lipase (MAGL) inhibition… read more here.
Keywords: inhibitor abx; alcoholic liver; monoacylglycerol lipase; abx 1431 ... See more keywords