Chemical synthesis and antigenic activity of a phosphatidylinositol mannoside epitope from Mycobacterium tuberculosis.
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DOI: 10.1039/d0cc05573e
Abstract: Phosphatidylinositol mannosides (PIMs) have been investigated as lipidic antigens for a new subunit tuberculosis vaccine. A non-natural diacylated phosphatidylinositol mannoside (Ac2PIM2) was designed and synthesized by mimicking the natural PIM6 processing procedure in dentritic cells.… read more here.
Keywords: phosphatidylinositol; ac2pim2; building block; tuberculosis ... See more keywords