Abnormal ac4C modification in metabolic dysfunction associated steatotic liver cells
Sign Up to like & getrecommendations! Published in 2025 at "Scientific Reports"
DOI: 10.1038/s41598-024-84564-0
Abstract: The pathogenesis of metabolic dysfunction-associated steatotic liver disease (MASLD) remains unclear due to the complexity of its etiology. The emerging field of the epitranscriptome has shown significant promise in advancing the understanding of disease pathogenesis… read more here.
Keywords: steatotic liver; dysfunction associated; ac4c modification; metabolic dysfunction ... See more keywords
NAT10 PROMOTES PYROPTOSIS AND PANCREATIC INJURY OF SEVERE ACUTE PANCREATITIS THROUGH AC4C MODIFICATION OF NLRP3
Sign Up to like & getrecommendations! Published in 2025 at "Shock"
DOI: 10.1097/shk.0000000000002551
Abstract: ABSTRACT Severe acute pancreatitis (SAP) is a highly morbid acute digestive disorder linked to pyroptosis. N-acetyltransferase 10 (NAT10) facilitates the production of N4-acetylcytidine (ac4C) modifications in mRNA, thereby contributing to the progression of various diseases.… read more here.
Keywords: modification nlrp3; pyroptosis; ac4c modification; acute ... See more keywords
N-acetyltransferase 10 regulates alphavirus replication via N4-acetylcytidine (ac4C) modiļ¬cation of the lymphocyte antigen six family member E (LY6E) mRNA
Sign Up to like & getrecommendations! Published in 2024 at "Journal of Virology"
DOI: 10.1128/jvi.01350-23
Abstract: ABSTRACT Epitranscriptomic RNA modifications can regulate the stability of mRNA and affect cellular and viral RNA functions. The N4-acetylcytidine (ac4C) modification in the RNA viral genome was recently found to promote viral replication; however, the… read more here.
Keywords: replication; mrna; stability; ac4c modification ... See more keywords
NAT10-mediated ac4C modification of Lipin1 mRNA contributes to the pathogenesis of PWMI
Sign Up to like & getrecommendations! Published in 2025 at "JCI Insight"
DOI: 10.1172/jci.insight.193712
Abstract: Preterm white matter injury (PWMI) is a leading cause of cerebral palsy and chronic neurological disabilities in premature infants. It is characterized by defects in oligodendrocyte precursor cell (OPC) differentiation and dysmyelination. Currently, there are… read more here.
Keywords: lipin1; pwmi; lipin1 mrna; ac4c modification ... See more keywords
Electroacupuncture attenuates ac4C modification of P16 mRNA in the ovarian granulosa cells of a mouse model premature ovarian failure
Sign Up to like & getrecommendations! Published in 2022 at "Acupuncture in Medicine"
DOI: 10.1177/09645284221085284
Abstract: Background: Premature ovarian failure (POF) is a type of pathological aging, which seriously interferes with the fertility of affected women. Electroacupuncture (EA) may have a beneficial effect; however, its mechanism of action is unknown. The… read more here.
Keywords: modification p16; ac4c modification; p16; expression ... See more keywords