Comparative functional genomics of the acarbose producers reveals potential targets for metabolic engineering
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DOI: 10.1016/j.synbio.2019.01.001
Abstract: The α-glucosidase inhibitor acarbose is produced in large-scale by strains derived from Actinoplanes sp. SE50 and used widely for the treatment of type-2 diabetes. Compared with the wild-type SE50, a high-yield derivative Actinoplanes sp. SE50/110… read more here.
Keywords: engineering; acarbose yield; acb cluster; yield ... See more keywords