Nanodisc scaffold peptide (NSPr) replaces detergent by reconstituting acyl-CoA:cholesterol acyltransferase 1 into peptidiscs.
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DOI: 10.1016/j.abb.2020.108518
Abstract: To conduct biochemical studies in vitro, membrane proteins (MPs) must be solubilized with detergents. While detergents are great tools, they can also inhibit the biological activity and/or perturb oligomerization of individual MPs. Nanodisc scaffold peptide… read more here.
Keywords: acat1 peptidiscs; cholesterol; detergent; peptidiscs ... See more keywords