ACBP/DBI protein neutralization confers autophagy-dependent organ protection through inhibition of cell loss, inflammation, and fibrosis
Sign Up to like & getrecommendations! Published in 2022 at "Proceedings of the National Academy of Sciences of the United States of America"
DOI: 10.1073/pnas.2207344119
Abstract: Significance Pharmacological induction of autophagy usually involves small molecules targeting intracellular signaling cascades. Here, Motiño et al. demonstrate that monoclonal antibody–mediated neutralization of an extracellular inhibitor of autophagy, acyl-coenzyme A binding protein (ACBP)/diazepam-binding inhibitor (DBI),… read more here.
Keywords: cell loss; dbi; loss inflammation; inflammation fibrosis ... See more keywords
Antibody-mediated neutralization of ACBP/DBI has anorexigenic and lipolytic effects
Sign Up to like & getrecommendations! Published in 2020 at "Adipocyte"
DOI: 10.1080/21623945.2020.1736734
Abstract: ABSTRACT We recently identified acyl coenzyme A-binding protein (ACBP)/diazepam binding inhibitor (DBI) as a novel ‘hunger factor’: a protein that is upregulated in human or murine obesity and that, if administered to mice, causes hyperphagy,… read more here.
Keywords: acbp dbi; dbi anorexigenic; neutralization acbp; dbi ... See more keywords