Diversity oriented biosynthesis via accelerated evolution of modular gene clusters
Sign Up to like & getrecommendations! Published in 2017 at "Nature Communications"
DOI: 10.1038/s41467-017-01344-3
Abstract: Erythromycin, avermectin and rapamycin are clinically useful polyketide natural products produced on modular polyketide synthase multienzymes by an assembly-line process in which each module of enzymes in turn specifies attachment of a particular chemical unit.… read more here.
Keywords: accelerated evolution; evolution; polyketide synthase; evolution modular ... See more keywords
Accelerated evolution and diversifying selection drove the adaptation of cetacean bone microstructure
Sign Up to like & getrecommendations! Published in 2019 at "BMC Evolutionary Biology"
DOI: 10.1186/s12862-019-1509-x
Abstract: BackgroundThe transition from land to sea by the ancestor of cetaceans approximately 50 million years ago was an incredible evolutionary event that led to a series of morphological, physiological, and behavioral adaptations. During this transition,… read more here.
Keywords: accelerated evolution; bone; selection; bone microstructure ... See more keywords