Impaired mitochondrial stress response in cumulus cells is associated with increased apoptosis and accelerated follicular depletion
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DOI: 10.1016/j.fertnstert.2018.07.300
Abstract: OBJECTIVE: Caseinolytic peptidase P (CLPP) mediates degradation of mitochondrial misfolded proteins to maintain homeostasis under metabolic stress. CLPP is a key factor for mitochondrial function and targeted global germline deletion of Clpp results in female… read more here.
Keywords: cumulus cells; accelerated follicular; follicular depletion; stress ... See more keywords