Developmental Loci Harbor Clusters of Accelerated Regions That Evolved Independently in Ape Lineages
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DOI: 10.1093/molbev/msy109
Abstract: Abstract Some of the fastest evolving regions of the human genome are conserved noncoding elements with many human-specific DNA substitutions. These human accelerated regions (HARs) are enriched nearby regulatory genes, and several HARs function as… read more here.
Keywords: accelerated regions; developmental loci; harbor clusters; loci harbor ... See more keywords
Enhancer Function and Evolutionary Roles of Human Accelerated Regions.
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DOI: 10.1146/annurev-genet-071819-103933
Abstract: Human accelerated regions (HARs) are the fastest-evolving sequences in the human genome. When HARs were discovered in 2006, their function was mysterious due to scant annotation of the noncoding genome. Diverse technologies, from transgenic animals… read more here.
Keywords: function evolutionary; enhancer function; human accelerated; accelerated regions ... See more keywords
A Systematic Review of the Human Accelerated Regions in Schizophrenia and Related Disorders: Where the Evolutionary and Neurodevelopmental Hypotheses Converge
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DOI: 10.3390/ijms24043597
Abstract: Schizophrenia is a psychiatric disorder that results from genetic and environmental factors interacting and disrupting neurodevelopmental trajectories. Human Accelerated Regions (HARs) are evolutionarily conserved genomic regions that have accumulated human-specific sequence changes. Thus, studies on… read more here.
Keywords: review; related disorders; schizophrenia related; human accelerated ... See more keywords