Replication of the Enzymatic Temperature Dependency of the Primary Hydride Kinetic Isotope Effects in Solution: Caused by the Protein Controlled Rigidity of the Donor-Acceptor Centers?
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DOI: 10.1021/acs.biochem.9b00574
Abstract: The change from temperature independence of the primary (1°) H/D kinetic isotope effects (KIEs) in wild-type enzyme catalyzed H-transfer reactions (∆Ea = EaD - EaH ~ 0) to strong temperature dependence with the mutated enzymes… read more here.
Keywords: temperature; isotope effects; donor acceptor; acceptor centers ... See more keywords