Synthesis of Pyrimidines and Quinazolines via Acceptorless Dehydrogenative Coupling Catalysed by PNN‐Pd Complex
Sign Up to like & getrecommendations! Published in 2025 at "Asian Journal of Organic Chemistry"
DOI: 10.1002/ajoc.202500165
Abstract: Herein, we report the catalytic application of PdIIPNN [PNN: 2,6‐{(R2P)N(H)(C5H3N)(C2HN3C6H5)}] (L1 R = Ph; L2 R = tBu) pincer complexes (Pd1–Pd4) for the sustainable and cost‐effective synthesis of pharmacologically important pyrimidines and quinazolines by acceptorless… read more here.
Keywords: pnn; acceptorless dehydrogenative; pyrimidines quinazolines; synthesis ... See more keywords
Binuclear Ruthenium (II) Catalyzed Selective α‐Alkenylation of Amide via Acceptorless Dehydrogenative Coupling of Alcohols
Sign Up to like & getrecommendations! Published in 2025 at "Applied Organometallic Chemistry"
DOI: 10.1002/aoc.70411
Abstract: Herein, we report an effective catalytic methodology for the construction of α,β‐unsaturated amides via acceptorless dehydrogenative coupling (ADC) of alcohols using newly synthesized binuclear ruthenium (II) complex [(η6‐p‐cymene)2Ru2Cl2(μ‐L)] (where L = N′‐4‐fluoro benzoyl‐4‐fluorobenzohydrazide) as catalyst. The structural… read more here.
Keywords: ruthenium; via acceptorless; acceptorless dehydrogenative; alkenylation amide ... See more keywords
Phosphine Ligand‐Free Ruthenium Complexes as Efficient Catalysts for the Synthesis of Quinolines and Pyridines by Acceptorless Dehydrogenative Coupling Reactions
Sign Up to like & getrecommendations! Published in 2019 at "ChemCatChem"
DOI: 10.1002/cctc.201900435
Abstract: A series of phosphine‐free Ru(III)/Ru(II) complexes of NH functionalized N˄N˄N pincer ligands exhibit excellent activity for acceptorless dehydrogenative coupling (ADC) of secondary alcohols with 2‐aminobenzyl or γ‐amino alcohols to quinolines and pyridines. Ru(III) complexes [LRuCl3]… read more here.
Keywords: acceptorless dehydrogenative; iii complexes; pyridin; quinolines pyridines ... See more keywords
A Heterogeneous Single Atom Cobalt Catalyst for Highly Efficient Acceptorless Dehydrogenative Coupling Reactions.
Sign Up to like & getrecommendations! Published in 2023 at "Small"
DOI: 10.1002/smll.202207941
Abstract: A fundamental understanding of metal active sites in single-atom catalysts (SACs) is important and challenging in the development of high-performance catalyst systems. Here, a highly efficient and straightforward molten-salt-assisted approach is reported to create atomically… read more here.
Keywords: cobalt; catalyst; single atom; highly efficient ... See more keywords
Ruthenium-catalyzed acceptorless dehydrogenative coupling of o-aminobenzyl alcohols with ketones to quinolines in the presence of carbonate salt
Sign Up to like & getrecommendations! Published in 2021 at "Journal of Catalysis"
DOI: 10.1016/j.jcat.2020.12.016
Abstract: Abstract A ruthenium complex bearing a functional 2,2′-bibenzimidazole ligand [(p-cymene)Ru(BiBzImH2)Cl][Cl] was designed, synthesized and found to be a general and highly efficient catalyst for the synthesis of quinolines via acceptorless dehydrogenative coupling of o-aminobenzyl alcohols… read more here.
Keywords: coupling aminobenzyl; alcohols ketones; acceptorless dehydrogenative; aminobenzyl alcohols ... See more keywords
Ruthenium-Catalyzed Divergent Acceptorless Dehydrogenative Coupling of 1,3-Diols with Arylhydrazines: Synthesis of Pyrazoles and 2-Pyrazolines.
Sign Up to like & getrecommendations! Published in 2022 at "Organic letters"
DOI: 10.1021/acs.orglett.2c01497
Abstract: Herein, the divergent transformations of 1,3-diols with arylhydrazines via acceptorless dehydrogenative coupling reactions to selectively synthesize pyrazoles and 2-pyrazolines were reported, which were based on Ru3(CO)12/NHC-phosphine-phosphine catalytic systems. The reactions featured low catalyst loading, high… read more here.
Keywords: ruthenium catalyzed; pyrazoles pyrazolines; diols arylhydrazines; acceptorless dehydrogenative ... See more keywords
Arene Binuclear Ru(II)-Promoted Sustainable Synthesis of Substituted Pyrazoles from Alcohols via Acceptorless Dehydrogenative Annulation.
Sign Up to like & getrecommendations! Published in 2023 at "Organic letters"
DOI: 10.1021/acs.orglett.3c01452
Abstract: We report a selective and sustainable synthesis of substituted pyrazoles via an eco-friendly acceptorless dehydrogenative annulation (ADA) of greener alcohols, malononitrile, and various aromatic hydrazides by newly synthesized binuclear Ru(II) p-cymene complexes. A discrete set… read more here.
Keywords: dehydrogenative annulation; synthesis substituted; sustainable synthesis; substituted pyrazoles ... See more keywords
Acceptorless Dehydrogenative Aminoalkylation of Allylic C(sp3)-H Bonds via Reversible Hydrogen Atom Transfer.
Sign Up to like & getrecommendations! Published in 2025 at "Organic letters"
DOI: 10.1021/acs.orglett.5c01300
Abstract: Photoinduced acceptorless dehydrogenative cross-coupling between the benzylic C(sp3)-H bonds of N-benzylanilines and the allylic C(sp3)-H bonds of alkenes was developed through the combined use of an Ir-based photosensitizer, silyl thiol, and 1,2,3-triazolium amidate as catalysts.… read more here.
Keywords: reversible hydrogen; acceptorless dehydrogenative; hydrogen atom; sp3 bonds ... See more keywords
Manganese Pincer Complexes for the Base-Free, Acceptorless Dehydrogenative Coupling of Alcohols to Esters: Development, Scope, and Understanding
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DOI: 10.1021/acscatal.6b03554
Abstract: Aliphatic PNP pincer-supported earth-abundant manganese(I) dicarbonyl complexes behave as effective catalysts for the acceptorless dehydrogenative coupling of a wide range of alcohols to esters under base-free conditions. The reaction proceeds under neat conditions, with modest… read more here.
Keywords: alcohols esters; base free; acceptorless dehydrogenative; dehydrogenative coupling ... See more keywords
Single-Atom Fe-Catalyzed Acceptorless Dehydrogenative Coupling to Quinolines.
Sign Up to like & getrecommendations! Published in 2024 at "Journal of the American Chemical Society"
DOI: 10.1021/jacs.4c06145
Abstract: A single-atom iron catalyst was found to exhibit exceptional reactivity in acceptorless dehydrogenative coupling for quinoline synthesis, outperforming known homogeneous and nanocatalyst systems. Detailed characterizations, including aberration-corrected HAADF-STEM, XANES, and EXAFS, jointly confirmed the presence… read more here.
Keywords: acceptorless dehydrogenative; atom catalyzed; catalyzed acceptorless; single atom ... See more keywords
Cobalt-catalyzed acceptorless dehydrogenative coupling of aminoalcohols with alcohols: direct access to pyrrole, pyridine and pyrazine derivatives.
Sign Up to like & getrecommendations! Published in 2017 at "Chemical communications"
DOI: 10.1039/c7cc07427a
Abstract: Here, the first example is reported of a new, molecularly defined SNS-cobalt(ii) catalyst for the acceptorless dehydrogenative coupling (ADC) of unprotected amino alcohols with secondary alcohols leading to pyrrole and pyridine derivatives. read more here.
Keywords: catalyzed acceptorless; cobalt catalyzed; pyrrole pyridine; acceptorless dehydrogenative ... See more keywords