Ketoreductase-Catalyzed Access to Axially Chiral 2,6-Disubstituted Spiro[3.3]heptane Derivatives.
Sign Up to like & getrecommendations! Published in 2022 at "Organic letters"
DOI: 10.1021/acs.orglett.2c01378
Abstract: The desymmetrization of a prochiral 6-oxaspiro[3.3]heptane-2-carboxylic acid derivative via biocatalytic ketoreductase-mediated reduction has provided access to both enantiomers in high ee. The axially chiral alcohol was converted to the corresponding ester alcohol, amino acid, and… read more here.
Keywords: ketoreductase catalyzed; catalyzed access; heptane; axially chiral ... See more keywords
Asymmetric rhodium-catalyzed click cycloaddition to access C–N axially chiral N-triazolyl indoles
Sign Up to like & getrecommendations! Published in 2023 at "Chemical Science"
DOI: 10.1039/d3sc00610g
Abstract: The copper-catalyzed azide–alkyne cycloaddition (CuAAC) reaction is regarded as a prime example of “click chemistry”, but the asymmetric click cycloaddition of internal alkynes still remains challenging. A new asymmetric Rh-catalyzed click cycloaddition of N-alkynylindoles with… read more here.
Keywords: catalyzed click; click cycloaddition; axially chiral; chiral triazolyl ... See more keywords