Access to Chiral Chromenones through Organocatalyzed Mannich/Annulation Sequence.
Sign Up to like & getrecommendations! Published in 2021 at "Organic letters"
DOI: 10.1021/acs.orglett.1c03010
Abstract: Herein we report an efficient and practical method to access chiral chromenones bearing one α-amino stereogenic center in the β position of the carbonyl group. The quinine-derived squaramide could efficiently promote Mannich/cycloketalization/dehydration tandem reactions between… read more here.
Keywords: organocatalyzed mannich; mannich annulation; access chiral; chromenones organocatalyzed ... See more keywords
Enantioselective Propargylation of Oxonium Ylide with α-Propargylic-3-Indolymethanol: Access to Chiral Propargylic Indoles.
Sign Up to like & getrecommendations! Published in 2022 at "Organic letters"
DOI: 10.1021/acs.orglett.1c04217
Abstract: An enantioselective three-component reaction of α-propargylic-3-indolymethanol with diazoindolinone and alcohol under cocatalysis of Rh(II) and chiral phosphoric acid (CPA) has been reported. It proceeds through the regio- and enantiospecific addition of the in situ formed… read more here.
Keywords: propargylic indolymethanol; propargylation oxonium; chiral propargylic; ylide propargylic ... See more keywords
Access to Chiral Tetrahydroquinazolines/1,3-Benzoxazines via Iridium-Catalyzed Asymmetric [4 + 2] Cycloaddition.
Sign Up to like & getrecommendations! Published in 2023 at "Organic letters"
DOI: 10.1021/acs.orglett.3c01004
Abstract: An iridium-catalyzed asymmetric [4 + 2] cycloaddition of 1,3,5-triazinanes with 2-(1-hydroxyallyl)anilines/2-(1-hydroxyallyl)phenols has been developed, providing a straightforward and efficient approach to a wide range of tetrahydroquinazolines in good yields and excellent enantioselectivities (up to >99%… read more here.
Keywords: asymmetric cycloaddition; catalyzed asymmetric; iridium catalyzed; access chiral ... See more keywords
Ruthenium-Catalyzed Hydrogenation of Carbocyclic Aromatic Amines: Access to Chiral Exocyclic Amines.
Sign Up to like & getrecommendations! Published in 2018 at "Organic letters"
DOI: 10.1021/acs.orglett.7b04060
Abstract: The first highly enantioselective hydrogenation of carbocyclic aromatic amines has been successfully realized using in situ-generated chiral ruthenium complex as catalyst, affording facile access to chiral exocyclic amines with up to 98% ee. read more here.
Keywords: carbocyclic aromatic; access chiral; aromatic amines; hydrogenation carbocyclic ... See more keywords
Access to Chiral GABA Analogues Bearing a Trifluoromethylated All-Carbon Quaternary Stereogenic Center through Water-Promoted Organocatalytic Michael Reactions.
Sign Up to like & getrecommendations! Published in 2019 at "Organic letters"
DOI: 10.1021/acs.orglett.9b02320
Abstract: Water enables the highly challenging enantioselective Michael addition of sterically congested β-trifluoromethyl-β-aryl- or -alkyl-substituted nitroolefins with dithiomalonates. Under on-water conditions, the reaction rates were remarkably accelerated as a result of enforced hydrophobic interactions between catalysts… read more here.
Keywords: water; michael; gaba analogues; access chiral ... See more keywords
Modular and Facile Access to Chiral α-Aryl Phosphates via Dual Nickel- and Photoredox-Catalyzed Reductive Cross-Coupling.
Sign Up to like & getrecommendations! Published in 2022 at "Journal of the American Chemical Society"
DOI: 10.1021/jacs.1c12424
Abstract: Chiral phosphine-containing skeletons are important motifs in bioactive natural products, pharmaceuticals, chiral catalysts, and ligands. Herein, we report a general and modular platform to access chiral α-aryl phosphorus compounds via a Ni/photoredox-catalyzed enantioconvergent reductive cross-coupling… read more here.
Keywords: access chiral; cross coupling; photoredox catalyzed; reductive cross ... See more keywords
A practical strategy to access chiral α-aryloxy carboxylic acids through ion-pairing directed asymmetric hydrogenation
Sign Up to like & getrecommendations! Published in 2020 at "Organic chemistry frontiers"
DOI: 10.1039/d0qo01205j
Abstract: A series of optically active α-aryloxy functionalized carboxylic acids were obtained via non-covalent interaction assisted highly efficient asymmetric hydrogenation. read more here.
Keywords: access chiral; carboxylic acids; asymmetric hydrogenation; practical strategy ... See more keywords
Primary trifluoroborate-iminiums enable facile access to chiral α-aminoboronic acids via Ru-catalyzed asymmetric hydrogenation and simple hydrolysis of the trifluoroborate moiety
Sign Up to like & getrecommendations! Published in 2022 at "Chemical Science"
DOI: 10.1039/d1sc07065g
Abstract: This work describes the first preparation and application of primary trifluoroborate-iminiums (pTIMs) as a new, easily accessible and valuable class of organoboron derivatives. An array of structurally diverse pTIMs was prepared from potassium acyltrifluoroborates in… read more here.
Keywords: primary trifluoroborate; aminoboronic acids; chiral aminoboronic; access chiral ... See more keywords