Access to Functionalized Pyridoindolones Enabled by Rh(III)‐Catalyzed C─H Alkenylation/Cyclization of Indoles with Alkynes
Sign Up to like & getrecommendations! Published in 2025 at "Asian Journal of Organic Chemistry"
DOI: 10.1002/ajoc.70220
Abstract: Herein, we report a traceless directing group assisted Rh(III)‐catalyzed C─H cyclization cascade of indoles and (arylprop‐2‐yn‐1‐yl)malonates under redox‐free reaction conditions, thus providing a concise access to structurally diverse functionalized pyridoindolones. This transformation proceed smoothly with… read more here.
Keywords: functionalized pyridoindolones; cyclization; pyridoindolones enabled; access functionalized ... See more keywords
Oxidative Ring Expansion of Cyclobutanols: Access to Functionalized 1,2-Dioxanes.
Sign Up to like & getrecommendations! Published in 2021 at "Organic letters"
DOI: 10.1021/acs.orglett.1c00070
Abstract: Cyclobutanols undergo an oxidative ring expansion with Co(acac)2 and triplet oxygen to give 1,2-dioxanols. The formation of an alkoxy radical drives the regioselective cleavage of the ring on the more substituted side before insertion of… read more here.
Keywords: oxidative ring; ring expansion; cyclobutanols access; expansion cyclobutanols ... See more keywords
Tandem Reaction of Azide with Isonitrile and TMSCnFm(H): Access to N-Functionalized C-Fluoroalkyl Amidine.
Sign Up to like & getrecommendations! Published in 2023 at "Organic letters"
DOI: 10.1021/acs.orglett.3c00125
Abstract: N-Functionalized C-fluoroalkyl amidines are attracting great attention due to their potential in pharmaceuticals. Herein, we report a Pd-catalyzed tandem reaction of azide with isonitrile and fluoroalkylsilane via a carbodiimide intermediate, providing facile access to N-functionalized… read more here.
Keywords: reaction azide; functionalized fluoroalkyl; access functionalized; azide isonitrile ... See more keywords
HFIP-Mediated Spiro-annulation of Bicyclo[1.1.0]butanes with α-Halo Hydroxamates: Access to Functionalized Spirocyclobutenes.
Sign Up to like & getrecommendations! Published in 2025 at "Organic letters"
DOI: 10.1021/acs.orglett.5c02493
Abstract: Bicyclo[1.1.0]butanes (BCBs) are activated using photocatalysts, Lewis and Brønsted acids, transition metal catalysts, and more recently hexafluoroisopropanol (HFIP). On the other hand, α-halo hydroxamates are known to generate reactive azaoxyallyl cations in the presence of… read more here.
Keywords: spiro annulation; functionalized spirocyclobutenes; halo hydroxamates; bicyclo butanes ... See more keywords
Photoredox Catalysis Enables Access to N-Functionalized 2,1-Borazaronaphthalenes.
Sign Up to like & getrecommendations! Published in 2019 at "Organic letters"
DOI: 10.1021/acs.orglett.9b00884
Abstract: The synthesis and utilization of a class of 2,1-borazaronaphthyltrifluoroborate reagents that provide a general solution to the challenge of N-functionalization of the 2,1-borazaronaphthalene core is described. By adorning the nitrogen of this core with a… read more here.
Keywords: functionalized borazaronaphthalenes; enables access; photoredox catalysis; access functionalized ... See more keywords
Modular Access to Functionalized Oxetanes as Benzoyl Bioisosteres.
Sign Up to like & getrecommendations! Published in 2024 at "Journal of the American Chemical Society"
DOI: 10.1021/jacs.4c04504
Abstract: Bioisosterism is a valuable principle exploited in drug discovery to fine-tune physicochemical properties of bioactive compounds. Functionalized 3-aryl oxetanes, as an important class of bioisosteres for benzoyl groups (highly prevalent structures in approved drugs), have… read more here.
Keywords: access; modular access; benzoyl bioisosteres; functionalized oxetanes ... See more keywords
Access to functionalized luminescent Pt(II) complexes by photoredox-catalyzed Minisci alkylation of 6-aryl-2,2'-bipyridines.
Sign Up to like & getrecommendations! Published in 2021 at "Chemical communications"
DOI: 10.1039/d0cc07307e
Abstract: Photoredox-mediated C-H bond alkylation of 6-aryl-2,2'-bipyridines with N-(acyloxy)phthalimides is reported. The reaction exhibits excellent functional group tolerance, including chiral aliphatic groups. The influence of the incorporated C6'-alkyl group on the photophysical properties of the corresponding… read more here.
Keywords: aryl bipyridines; alkylation aryl; functionalized luminescent; access functionalized ... See more keywords