Access to Indole-Annulated Medium-Sized Lactams through Protonation/Deuteration-Induced Ring-Opening of Spiroindolines
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DOI: 10.1021/acsomega.1c04261
Abstract: A protocol has been developed to access indole-annulated eight- and nine-membered lactams through protonation-induced ring-opening of spiroindolines, which are dearomative Heck products of tetrahydro-β-carbolines or hexahydroazepino[3,4-b]indoles. Brønsted acids and nucleophiles were explored and compared in… read more here.
Keywords: ring opening; access indole; induced ring; opening spiroindolines ... See more keywords