Access to Substituted Propenoic Acids via Rh(III)-Catalyzed C-H Allylation of (Hetero)Arenes with Methyleneoxetanones.
Sign Up to like & getrecommendations! Published in 2017 at "Organic letters"
DOI: 10.1021/acs.orglett.7b02983
Abstract: An efficient synthesis of disubstituted acrylic acids has been realized via Rh(III)-catalyzed C-H activation of (hetero)arenes and coupling with four-membered methyleneoxetanones under redox-neutral conditions. In most cases, the reactions are silver-free, and the products are… read more here.
Keywords: hetero arenes; via iii; access substituted; iii catalyzed ... See more keywords
Three-Component Oxyarylation of Alkenes Enables Access to C3-Substituted Dihydrobenzofurans.
Sign Up to like & getrecommendations! Published in 2018 at "Organic letters"
DOI: 10.1021/acs.orglett.8b03278
Abstract: A practical and modular three-component alkene oxyarylation with benzoquinone and H2O to rapidly access C3-substituted dihydrobenzofurans has been developed. The (NH4)2S2O8-mediated redox-relay process has an excellent regioselectivity and functional group tolerance and exhibits a broad… read more here.
Keywords: substituted dihydrobenzofurans; three component; component oxyarylation; access substituted ... See more keywords
Modular access to substituted germoles by intramolecular germylzincation.
Sign Up to like & getrecommendations! Published in 2022 at "Chemical communications"
DOI: 10.1039/d1cc07163g
Abstract: Intramolecular alkyne germylzincation giving access to a wide range of germoles is achieved from triarylhydrogermanes in the presence of diethylzinc and AIBN as radical initiator. The reaction proceeds through activation of the Ge-H bond, leading… read more here.
Keywords: germylzincation; modular access; access substituted; substituted germoles ... See more keywords
Diastereoselective access to substituted oxetanes via hydrosilylation-iodocyclisation of homopropargylic alcohols.
Sign Up to like & getrecommendations! Published in 2022 at "Chemical communications"
DOI: 10.1039/d2cc03339a
Abstract: The regio and stereoselective hydrosilylation of a variety of homopropargylic alcohols and their derivatives is described. The reaction is tolerant to a variety of sterically and electronically varied substrates, affording only the E-vinyl silane as… read more here.
Keywords: substituted oxetanes; diastereoselective access; access substituted; homopropargylic alcohols ... See more keywords
A facile access to 1-substituted and unsubstituted 3-isoquinolinones via Mannich or Sn2 initiated cascade reactions under catalyst-free conditions
Sign Up to like & getrecommendations! Published in 2023 at "RSC Advances"
DOI: 10.1039/d3ra00378g
Abstract: Herein we report new cascade processes for the easy access to 1-substituted and C-unsubstituted 3-isoquinolinones. The Mannich initiated cascade reaction led to the synthesis of novel 1-substituted 3-isoquinolinones under catalyst-free conditions in the presence of… read more here.
Keywords: free conditions; access substituted; catalyst free; initiated cascade ... See more keywords
Modular access to substituted cyclohexanes with kinetic stereocontrol
Sign Up to like & getrecommendations! Published in 2022 at "Science"
DOI: 10.1126/science.abn9124
Abstract: Substituted six-membered cyclic hydrocarbons are common constituents of biologically active compounds. Although methods for the synthesis of thermodynamically favored, disubstituted cyclohexanes are well established, a reliable and modular protocol for the synthesis of their stereoisomers… read more here.
Keywords: access substituted; kinetic stereocontrol; disubstituted cyclohexanes; modular access ... See more keywords