Organocatalytic Access to Tetrasubstituted Chiral Carbons Integrating Functional Groups.
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DOI: 10.1002/tcr.202200200
Abstract: Three-dimensional organic structures containing sp3 carbons bearing four non-hydrogen substituents can provide drug-like molecules. Although such complex structures are challenging targets in synthetic organic chemistry, efficient synthetic approaches will open a new chemical space for… read more here.
Keywords: functional groups; organocatalytic access; tetrasubstituted chiral; chiral carbons ... See more keywords
Halotrifluoromethylation of 1,3-Enynes: Access to Tetrasubstituted Allenes.
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DOI: 10.1021/acs.orglett.1c00449
Abstract: A highly regioselective copper-catalyzed 1,4-chloro- and bromotrifluoromethylation of 1,3-enynes has been presented for the first time, which affords an efficient transformation to access halo- and CF3-containing tetrasubstituted allene derivatives with good to excellent yield. This… read more here.
Keywords: enynes access; tetrasubstituted allenes; halotrifluoromethylation enynes; access tetrasubstituted ... See more keywords
Versatile Access to Tetrasubstituted 2-Amidoacroleins through Formal Silylformylation of Ynamides.
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DOI: 10.1021/acs.orglett.1c03141
Abstract: In this paper we are reporting the first regio- and stereoselective silylformylation of ynamides. This reaction is tolerant to a wide range of functional groups around the ynamides. The substitution of CO by an isocyanide… read more here.
Keywords: silylformylation; silylformylation ynamides; access tetrasubstituted; tetrasubstituted amidoacroleins ... See more keywords