Dynamic folding and accessibility of telomeric overhang
Sign Up to like & getrecommendations! Published in 2022 at "Proceedings of the National Academy of Sciences of the United States of America"
DOI: 10.1073/pnas.2211219119
Abstract: The evolution of linear chromosomes in eukaryotes poses several challenges for the natural ends of chromosomes, such as misrecognition as DNA damage repair (DDR) sites, DNA degradation, and incomplete DNA replication. A solution to these… read more here.
Keywords: single stranded; dna; accessibility; accessibility telomeric ... See more keywords
Interrogating accessibility of telomeric sequences with FRET-PAINT: evidence for length-dependent telomere compaction
Sign Up to like & getrecommendations! Published in 2021 at "Nucleic Acids Research"
DOI: 10.1093/nar/gkab067
Abstract: Abstract Single-stranded telomeric overhangs are ∼200 nucleotides long and can form tandem G-quadruplex (GQ) structures, which reduce their accessibility to nucleases and proteins that activate DNA damage response. Whether these tandem GQs further stack to… read more here.
Keywords: interrogating accessibility; accessibility; fret paint; telomeric sequences ... See more keywords
Shelterin reduces the accessibility of telomeric overhangs
Sign Up to like & getrecommendations! Published in 2022 at "Nucleic Acids Research"
DOI: 10.1093/nar/gkac1176
Abstract: Abstract Telomeres terminate with a 50–300 bases long single-stranded G-rich overhang, which can be misrecognized as a DNA damage repair site. Shelterin plays critical roles in maintaining and protecting telomere ends by regulating access of… read more here.
Keywords: shelterin reduces; accessibility; telomeric overhangs; accessibility telomeric ... See more keywords