Oxysterols provide innate immunity to bacterial infection by mobilizing cell surface accessible cholesterol
Sign Up to like & getrecommendations! Published in 2020 at "Nature Microbiology"
DOI: 10.1038/s41564-020-0701-5
Abstract: Cholesterol 25-hydroxylase ( CH25H ) is an interferon-stimulated gene that converts cholesterol to the oxysterol 25-hydroxycholesterol (25HC). Circulating 25HC modulates essential immunological processes including antiviral immunity, inflammasome activation and antibody class switching; and dysregulation of… read more here.
Keywords: immunity; infection; plasma membrane; cholesterol ... See more keywords
Inflammatory stress signaling via NF-kB alters accessible cholesterol to upregulate SREBP2 transcriptional activity in endothelial cells
Sign Up to like & getrecommendations! Published in 2022 at "eLife"
DOI: 10.1101/2022.05.05.490737
Abstract: There is a growing appreciation that a tight relationship exists between cholesterol homeostasis and immunity in leukocytes, however, this relationship has not been deeply explored in the vascular endothelium. Endothelial cells (ECs) rapidly respond to… read more here.
Keywords: endothelial cells; accessible cholesterol; cholesterol homeostasis; cholesterol ... See more keywords