ESCRT-III accessory proteins regulate fungal development and plant infection in Fusarium graminearum
Sign Up to like & getrecommendations! Published in 2019 at "Current Genetics"
DOI: 10.1007/s00294-019-00949-z
Abstract: Ubiquitinated biosynthetic and surface proteins destined for degradation are sorted into the lysosome/vacuole via the multivesicular body sorting pathway, which depends on the function of ESCRT machinery. Fusarium head blight (FHB) caused by Fusarium graminearum… read more here.
Keywords: escrt iii; fusarium; graminearum; accessory proteins ... See more keywords
The importance of accessory protein variants in the pathogenicity of SARS-CoV-2
Sign Up to like & getrecommendations! Published in 2022 at "Archives of Biochemistry and Biophysics"
DOI: 10.1016/j.abb.2022.109124
Abstract: The coronavirus disease 2019 (COVID-19) is caused by the Severe Acute Respiratory Syndrome Coronavirus-2 (SARS- CoV-2) with an estimated fatality rate of less than 1%. The SARS-CoV-2 accessory proteins ORF3a, ORF6, ORF7a, ORF7b, ORF8, and… read more here.
Keywords: pathogenicity sars; sars cov; importance accessory; accessory proteins ... See more keywords
Regulation of GABAARs by Transmembrane Accessory Proteins
Sign Up to like & getrecommendations! Published in 2021 at "Trends in Neurosciences"
DOI: 10.1016/j.tins.2020.10.011
Abstract: The vast majority of fast inhibitory transmission in the brain is mediated by GABA acting on GABAA receptors (GABAARs), which provides inhibitory balance to excitatory drive and controls neuronal output. GABAARs are also effectively targeted… read more here.
Keywords: regulation gabaars; gabaars transmembrane; accessory proteins; pharmacology ... See more keywords
Genomic evolution of the Coronaviridae family
Sign Up to like & getrecommendations! Published in 2022 at "Virology"
DOI: 10.1016/j.virol.2022.03.005
Abstract: The current outbreak of coronavirus disease-2019 (COVID-19) caused by SARS-CoV-2 poses unparalleled challenges to global public health. SARS-CoV-2 is a Betacoronavirus, one of four genera belonging to the Coronaviridae subfamily Orthocoronavirinae. Coronaviridae, in turn, are… read more here.
Keywords: genomic evolution; coronaviridae family; evolution; evolution coronaviridae ... See more keywords
HECT ubiquitin ligases as accessory proteins of the plant proteasome
Sign Up to like & getrecommendations! Published in 2022 at "Essays in Biochemistry"
DOI: 10.1042/ebc20210064
Abstract: Abstract The proteasome plays vital roles in eukaryotic cells by orchestrating the regulated degradation of large repertoires of substrates involved in numerous biological processes. Proteasome dysfunction is associated with a wide variety of human pathologies… read more here.
Keywords: proteasome; ubiquitin ligases; plant; accessory proteins ... See more keywords
MERS-CoV endoribonuclease and accessory proteins jointly evade host innate immunity during infection of lung and nasal epithelial cells
Sign Up to like & getrecommendations! Published in 2022 at "Proceedings of the National Academy of Sciences of the United States of America"
DOI: 10.1073/pnas.2123208119
Abstract: Significance Middle East respiratory syndrome coronavirus (MERS-CoV) causes highly lethal respiratory disease. MERS-CoV encodes innate immune antagonists, including accessory proteins NS4a and NS4b, unique to the merbeco lineage of betacoronaviruses, and the nsp15 protein endoribonuclease… read more here.
Keywords: host innate; innate immunity; mers cov; accessory proteins ... See more keywords
SARS-CoV-2 accessory proteins ORF7a and ORF3a use distinct mechanisms to down-regulate MHC-I surface expression
Sign Up to like & getrecommendations! Published in 2022 at "Proceedings of the National Academy of Sciences of the United States of America"
DOI: 10.1073/pnas.2208525120
Abstract: Significance Viruses may downregulate MHC class I expression on infected cells to avoid elimination by cytotoxic T cells. We report that the accessory proteins ORF7a and ORF3a of SARS-CoV-2 mediate this function and delineate the… read more here.
Keywords: expression; orf7a orf3a; distinct mechanisms; accessory proteins ... See more keywords
RAMP and MRAP Accessory Proteins have Selective Effects on Expression and Signalling of the CB1, CB2, GPR18 and GPR55 Cannabinoid Receptors.
Sign Up to like & getrecommendations! Published in 2023 at "British journal of pharmacology"
DOI: 10.1111/bph.16095
Abstract: BACKGROUND AND PURPOSE Receptor activity-modifying proteins (RAMPs) and melanocortin receptor accessory proteins (MRAPs) modulate expression and signalling of calcitonin and melanocortin GPCRs. Interactions with other GPCRs have also been reported. Cannabinoid receptors (CBRs) CB1 and… read more here.
Keywords: accessory proteins; gpr18; cb1 cb2; expression ... See more keywords
Homologyâbased classification of accessory proteins in coronavirus genomes uncovers extremely dynamic evolution of gene content
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DOI: 10.1111/mec.16531
Abstract: Coronaviruses (CoVs) have complex genomes that encode a fixed array of structural and nonstructural components, as well as a variety of accessory proteins that differ even among closely related viruses. Accessory proteins often play a… read more here.
Keywords: accessory; cov; dynamic evolution; accessory proteins ... See more keywords
Insight into the emerging role of SARS-CoV-2 nonstructural and accessory proteins in modulation of multiple mechanisms of host innate defense
Sign Up to like & getrecommendations! Published in 2021 at "Bosnian Journal of Basic Medical Sciences"
DOI: 10.17305/bjbms.2020.5543
Abstract: Coronavirus disease-19 (COVID-19) is an extremely infectious disease caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) that has become a major global health concern. The induction of a coordinated immune response is crucial to… read more here.
Keywords: insight emerging; accessory proteins; role; host ... See more keywords
Accessory Proteins of the Nitrogenase Assembly, NifW, NifX/NafY, and NifZ, Are Essential for Diazotrophic Growth in the Nonheterocystous Cyanobacterium Leptolyngbya boryana
Sign Up to like & getrecommendations! Published in 2019 at "Frontiers in Microbiology"
DOI: 10.3389/fmicb.2019.00495
Abstract: Since nitrogenase is extremely vulnerable to oxygen, aerobic or micro-aerobic nitrogen-fixing organisms need to create anaerobic microenvironments in the cells for diazotrophic growth, which would be one of the major barriers to express active nitrogenase… read more here.
Keywords: diazotrophic growth; nifw nifx; accessory proteins; nifx nafy ... See more keywords