Iron overload is accompanied by mitochondrial and lysosomal dysfunction in WDR45 mutant cells
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DOI: 10.1093/brain/awy230
Abstract: Beta-propeller protein-associated neurodegeneration is a subtype of monogenic neurodegeneration with brain iron accumulation caused by de novo mutations in WDR45. The WDR45 protein functions as a beta-propeller scaffold and plays a putative role in autophagy… read more here.
Keywords: mutant cells; wdr45 mutant; iron overload; iron ... See more keywords