Projections from D2 Neurons in Different Subregions of Nucleus Accumbens Shell to Ventral Pallidum Play Distinct Roles in Reward and Aversion.
Sign Up to like & getrecommendations! Published in 2021 at "Neuroscience bulletin"
DOI: 10.1007/s12264-021-00632-9
Abstract: The nucleus accumbens shell (NAcSh) plays an important role in reward and aversion. Traditionally, NAc dopamine receptor 2-expressing (D2) neurons are assumed to function in aversion. However, this has been challenged by recent reports which… read more here.
Keywords: accumbens shell; aversion; projections neurons; reward aversion ... See more keywords
Topographic transcriptomics of the nucleus accumbens shell: Identification and validation of fatty acid binding protein 5 as target for cocaine addiction
Sign Up to like & getrecommendations! Published in 2021 at "Neuropharmacology"
DOI: 10.1016/j.neuropharm.2020.108398
Abstract: Substance use disorders for cocaine are major public health concerns with few effective treatment options. Therefore, identification of novel pharmacotherapeutic targets is critical for future therapeutic development. Evolution has ensured that genes are expressed largely… read more here.
Keywords: seed; accumbens shell; analysis; fatty acid ... See more keywords
Cocaine self-administration specifically increases A2AR-D2R and D2R-sigma1R heteroreceptor complexes in the rat nucleus accumbens shell. Relevance for cocaine use disorder
Sign Up to like & getrecommendations! Published in 2017 at "Pharmacology Biochemistry and Behavior"
DOI: 10.1016/j.pbb.2017.03.003
Abstract: &NA; Adenosine 2A receptor (A2AR) agonists were indicated to reduce cocaine reward and cocaine seeking mainly through activation of antagonistic allosteric A2AR‐dopamine D2R (D2R) interactions in A2AR‐D2R heteroreceptor complexes. Furthermore, it was shown that modulation… read more here.
Keywords: d2r; accumbens shell; heteroreceptor complexes; a2ar d2r ... See more keywords
Effect of microinjections of dopamine into the nucleus accumbens shell on emission of 50 kHz USV: Comparison with effects of d-amphetamine
Sign Up to like & getrecommendations! Published in 2019 at "Pharmacology Biochemistry and Behavior"
DOI: 10.1016/j.pbb.2018.11.006
Abstract: ABSTRACT Systemic pharmacological manipulation of dopamine (DA) signaling has been central to many investigations of 50 kHz ultrasonic vocalizations (USVs) in the rat. In particular, the indirect DA releaser d‐amphetamine (AMPH) has been used extensively… read more here.
Keywords: accumbens shell; khz; dopamine; emission khz ... See more keywords
A-Kinase Anchoring Protein 150 (AKAP150) Promotes Cocaine Reinstatement by Increasing AMPA Receptor Transmission in the Accumbens Shell
Sign Up to like & getrecommendations! Published in 2017 at "Neuropsychopharmacology"
DOI: 10.1038/npp.2017.297
Abstract: Previous work indicated that activation of D1-like dopamine receptors (D1DRs) in the nucleus accumbens shell promoted cocaine seeking through a process involving the activation of PKA and GluA1-containing AMPA receptors (AMPARs). A-kinase anchoring proteins (AKAPs)… read more here.
Keywords: cocaine reinstatement; accumbens shell; reinstatement; transmission ... See more keywords
Role of neuropeptide neuromedin U in the nucleus accumbens shell in cocaine self-administration in male rats
Sign Up to like & getrecommendations! Published in 2021 at "Neuropsychopharmacology"
DOI: 10.1038/s41386-021-01234-9
Abstract: The nucleus accumbens shell (NAcSh) and its afferent and efferent neuronal projections control key aspects of motivation for cocaine. A recently described regulator of γ-aminobutyric acid (GABA) projections from the dorsal raphe nucleus (DRN) to… read more here.
Keywords: cocaine self; neuropeptide neuromedin; accumbens shell; administration ... See more keywords
Mu opioid receptor signaling in the nucleus accumbens shell increases responsiveness of satiety‐modulated lateral hypothalamus neurons
Sign Up to like & getrecommendations! Published in 2017 at "European Journal of Neuroscience"
DOI: 10.1111/ejn.13579
Abstract: Opioid signaling in the nucleus accumbens shell (sNAcc) has been implicated in hedonic feeding and binge eating behavior. The sNAcc projects to the lateral hypothalamus (LH), and this pathway has been suggested to modulate palatability‐driven… read more here.
Keywords: accumbens shell; infusion; signaling nucleus; satiety ... See more keywords
Synaptic ensembles between raphe and D1R-containing accumbens shell neurons underlie postisolation sociability in males
Sign Up to like & getrecommendations! Published in 2022 at "Science Advances"
DOI: 10.1126/sciadv.abo7527
Abstract: Social animals expend considerable energy to maintain social bonds throughout their life. Male and female mice show sexually dimorphic behaviors, yet the underlying neural mechanisms of sociability and their dysregulation during social disconnection remain unknown.… read more here.
Keywords: ensembles raphe; raphe d1r; accumbens shell; sociability ... See more keywords
Nicotine but not saline self-administering or yoked control conditions produces sustained neuroadaptations in the accumbens shell
Sign Up to like & getrecommendations! Published in 2023 at "Frontiers in Molecular Neuroscience"
DOI: 10.3389/fnmol.2023.1105388
Abstract: Introduction Using yoked animals as the control when monitoring operant drug-self-administration is considered the golden standard. However, instrumental learning per se recruits several neurocircuits that may produce distinct or overlapping neuroadaptations with drugs of abuse.… read more here.
Keywords: nicotine saline; accumbens shell; sustained neuroadaptations; produces sustained ... See more keywords