Accumulation of “Old Proteins” and the Critical Need for MS‐based Protein Turnover Measurements in Aging and Longevity
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DOI: 10.1002/pmic.201800403
Abstract: Aging and age‐related diseases are accompanied by proteome remodeling and progressive declines in cellular machinery required to maintain protein homeostasis (proteostasis), such as autophagy, ubiquitin‐mediated degradation, and protein synthesis. While many studies have focused on… read more here.
Keywords: protein; protein turnover; accumulation old; proteins critical ... See more keywords