IMPAIRED AUTOPHAGIC FLUX CONTRIBUTES TO THE ACCUMULATION OF UBIQUITINATED PROTEINS IN A MOUSE MODEL OF HEART FAILURE
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DOI: 10.1016/s0735-1097(17)34261-4
Abstract: Background: In the failing heart there is impaired protein turnover and an accumulation of ubiquitinated proteins within cardiomyocytes. This accumulation, which likely has detrimental effects on myocyte function, has been attributed to proteasome dysfunction. However,… read more here.
Keywords: heart; ubiquitinated proteins; accumulation ubiquitinated; autophagic flux ... See more keywords