Developing Next‐Generation Protein‐Based Vaccines Using High‐Affinity Glycan Ligand‐Decorated Glyconanoparticles
Sign Up to like & getrecommendations! Published in 2022 at "Advanced Science"
DOI: 10.1002/advs.202204598
Abstract: Major diseases, such as cancer and COVID‐19, are frightening global health problems, and sustained action is necessary to develop vaccines. Here, for the first time, ethoxy acetalated dextran nanoparticles (Ace‐Dex‐NPs) are functionalized with 9‐N‐(4H‐thieno[3,2‐c]chromene‐2‐carbamoyl)‐Siaα2−3Galβ1−4GlcNAc (TCCSia‐LacNAc)… read more here.
Keywords: ace dex; tccsia ace; sars cov; protein ... See more keywords
A robust microparticle platform for a STING‐targeted adjuvant that enhances both humoral and cellular immunity during vaccination
Sign Up to like & getrecommendations! Published in 2018 at "Journal of Controlled Release"
DOI: 10.1016/j.jconrel.2017.11.030
Abstract: Abstract Most FDA‐approved adjuvants for infectious agents boost humoral but not cellular immunity, and have poorly‐understood mechanisms. Stimulator of interferon genes (STING, also known as MITA, MPYS, or ERIS) is an exciting adjuvant target due… read more here.
Keywords: robust microparticle; immunity; humoral cellular; cgamp ... See more keywords