Generation of enzymatically competent SARS‐CoV‐2 decoy receptor ACE2‐Fc in glycoengineered Nicotiana benthamiana
Sign Up to like & getrecommendations! Published in 2021 at "Biotechnology Journal"
DOI: 10.1002/biot.202000566
Abstract: Human angiotensin‐converting enzyme 2 (ACE2) is the primary host cell receptor for severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2) binding and cell entry. Administration of high concentrations of soluble ACE2 can be utilized as a… read more here.
Keywords: glycoengineered nicotiana; ace2; receptor; sars cov ... See more keywords
GSK3326595 is a promising drug to prevent SARS‐CoV‐2 Omicron and other variants infection by inhibiting ACE2‐R671 di‐methylation
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Medical Virology"
DOI: 10.1002/jmv.28158
Abstract: The severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2) caused COVID‐19 epidemic is worsening. Binding of the Spike1 protein of SARS‐CoV‐2 with the angiotensin‐converting enzyme 2 (ACE2) receptor mediates entry of the virus into host cells.… read more here.
Keywords: mer671 ace2; methylation; infection; cov omicron ... See more keywords
Stimulation of ACE2/ANG(1–7)/Mas Axis by Diminazene Ameliorates Alzheimer’s Disease in the D-Galactose-Ovariectomized Rat Model: Role of PI3K/Akt Pathway
Sign Up to like & getrecommendations! Published in 2018 at "Molecular Neurobiology"
DOI: 10.1007/s12035-018-0966-3
Abstract: Overactivation of angiotensin-converting enzyme/angiotensin 2/angiotensin receptor-1 (ACE/Ang2/AT1) axis provokes amyloid-β-induced apoptosis and neurodegeneration in Alzheimer’s disease (AD). Moreover, activation of AT1 impairs the survival pathway phosphoinositide 3-kinase/protein kinase B (PI3K/Akt). Interestingly, the coupling between ACE2/Ang(1–7)/Mas… read more here.
Keywords: ang mas; ace2 ang; ace2; pi3k akt ... See more keywords
Far di Necessità Virtù, using rare tubulopathies, Gitelman’s and Bartter’s syndromes, to inform the fight against COVID-19
Sign Up to like & getrecommendations! Published in 2021 at "Journal of Nephrology"
DOI: 10.1007/s40620-020-00951-6
Abstract: The COVID-19 pandemic has called enormous scientific attention to angiotensin converting enzyme 2 (ACE2) and other components of the renin-angiotensin system (RAS) since ACE2 plays a central role as the viral receptor initiating the SARS-CoV-2… read more here.
Keywords: infection; ace2; covid; ang ... See more keywords
A model for COVID-19-induced dysregulation of ACE2 shedding by ADAM17
Sign Up to like & getrecommendations! Published in 2021 at "Biochemical and Biophysical Research Communications"
DOI: 10.1016/j.bbrc.2021.08.040
Abstract: The angiotensin Converting Enzyme 2 (ACE2) receptor is a key component of the renin-angiotensin-aldesterone system (RAAS) that mediates numerous effects in the cardiovascular system. It is also the cellular point of contact for the coronavirus… read more here.
Keywords: model covid; induced dysregulation; ace2; shedding adam17 ... See more keywords
Repurposing of approved drugs with potential to interact with SARS-CoV-2 receptor
Sign Up to like & getrecommendations! Published in 2021 at "Biochemistry and Biophysics Reports"
DOI: 10.1016/j.bbrep.2021.100982
Abstract: Respiratory transmission is the primary route of Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) infection. Angiotensin I converting enzyme 2 (ACE2) is the known receptor of SARS-CoV-2 surface spike glycoprotein for entry into human cells.… read more here.
Keywords: interact; ace2; approved drugs; ace1 ... See more keywords
The angiotensin converting enzyme 2/angiotensin-(1-7)/Mas Receptor axis as a key player in alveolar bone remodeling.
Sign Up to like & getrecommendations! Published in 2019 at "Bone"
DOI: 10.1016/j.bone.2019.115041
Abstract: The renin-angiotensin system (RAS), aside its classical hormonal properties, has been implicated in the pathogenesis of inflammatory disorders. The angiotensin converting enzyme 2/angiotensin-(1-7)/Mas Receptor (ACE2/Ang-(1-7)/MasR) axis owns anti-inflammatory properties and was recently associated with bone… read more here.
Keywords: masr; ace2; bone; alveolar bone ... See more keywords
Should ACE2 be given a chance in COVID-19 therapeutics: A semi-systematic review of strategies enhancing ACE2
Sign Up to like & getrecommendations! Published in 2020 at "European Journal of Pharmacology"
DOI: 10.1016/j.ejphar.2020.173545
Abstract: The severe acute respiratory syndrome corona virus-2 (SARS-CoV-2) has resulted in almost 18 million cases of COVID-19 (Corona virus disease-2019) and more than 670000 deaths worldwide since December 2019. In the absence of effective antiviral… read more here.
Keywords: semi systematic; systematic review; ace2; covid ... See more keywords
Design of an engineered ACE2 as a novel therapeutics against COVID-19
Sign Up to like & getrecommendations! Published in 2020 at "Journal of Theoretical Biology"
DOI: 10.1016/j.jtbi.2020.110425
Abstract: Abstract The interaction between the angiotensin-converting enzyme 2 (ACE2) and the receptor binding domain (RBD) of the spike protein from severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) plays a pivotal role in virus entry into… read more here.
Keywords: engineered ace2; ace2; interaction; sars cov ... See more keywords
Diminazene aceturate extenuate the renal deleterious consequences of angiotensin-II induced by γ-irradiation through boosting ACE2 signaling cascade.
Sign Up to like & getrecommendations! Published in 2020 at "Life sciences"
DOI: 10.1016/j.lfs.2020.117749
Abstract: AIM This work aims to explore the role of diminazene aceturate (DIZE) in the enhancement of angiotensin-converting enzyme-2 (ACE2) to prevent the inflammatory and fibrotic response induced by γ-irradiation through activating the protective axis ACE2/angiotensin… read more here.
Keywords: renal deleterious; irradiation; diminazene aceturate; ace2 ... See more keywords
Physiological and pathological regulation of ACE2, the SARS-CoV-2 receptor
Sign Up to like & getrecommendations! Published in 2020 at "Pharmacological Research"
DOI: 10.1016/j.phrs.2020.104833
Abstract: Abstract The renin-angiotensin system (RAS) is crucial for the physiology and pathology of all the organs. Angiotensin-converting enzyme 2 (ACE2) maintains the homeostasis of RAS as a negative regulator. Recently, ACE2 was identified as the… read more here.
Keywords: regulation ace2; physiological pathological; ace2; receptor ... See more keywords