Generation of enzymatically competent SARS‐CoV‐2 decoy receptor ACE2‐Fc in glycoengineered Nicotiana benthamiana
Sign Up to like & getrecommendations! Published in 2021 at "Biotechnology Journal"
DOI: 10.1002/biot.202000566
Abstract: Human angiotensin‐converting enzyme 2 (ACE2) is the primary host cell receptor for severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2) binding and cell entry. Administration of high concentrations of soluble ACE2 can be utilized as a… read more here.
Keywords: glycoengineered nicotiana; ace2; receptor; sars cov ... See more keywords
GSK3326595 is a promising drug to prevent SARS‐CoV‐2 Omicron and other variants infection by inhibiting ACE2‐R671 di‐methylation
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Medical Virology"
DOI: 10.1002/jmv.28158
Abstract: The severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2) caused COVID‐19 epidemic is worsening. Binding of the Spike1 protein of SARS‐CoV‐2 with the angiotensin‐converting enzyme 2 (ACE2) receptor mediates entry of the virus into host cells.… read more here.
Keywords: mer671 ace2; methylation; infection; cov omicron ... See more keywords
Elevated Soluble ACE2 Activity in Children and Adults After SARS‐CoV‐2 Exposure Irrespective of Laboratory‐Confirmed Infection
Sign Up to like & getrecommendations! Published in 2024 at "Journal of Medical Virology"
DOI: 10.1002/jmv.70098
Abstract: The pivotal role of the cell entry receptor ACE2 for SARS‐CoV‐2 infection is well‐established. When ACE2 is shed from cell surface into plasma as soluble ACE2 (sACE2), it can effectively neutralize SARS‐CoV‐2. This longitudinal prospective… read more here.
Keywords: sars cov; cov exposure; sace2; ace2 ... See more keywords
Stimulation of ACE2/ANG(1–7)/Mas Axis by Diminazene Ameliorates Alzheimer’s Disease in the D-Galactose-Ovariectomized Rat Model: Role of PI3K/Akt Pathway
Sign Up to like & getrecommendations! Published in 2018 at "Molecular Neurobiology"
DOI: 10.1007/s12035-018-0966-3
Abstract: Overactivation of angiotensin-converting enzyme/angiotensin 2/angiotensin receptor-1 (ACE/Ang2/AT1) axis provokes amyloid-β-induced apoptosis and neurodegeneration in Alzheimer’s disease (AD). Moreover, activation of AT1 impairs the survival pathway phosphoinositide 3-kinase/protein kinase B (PI3K/Akt). Interestingly, the coupling between ACE2/Ang(1–7)/Mas… read more here.
Keywords: ang mas; ace2 ang; ace2; pi3k akt ... See more keywords
Far di Necessità Virtù, using rare tubulopathies, Gitelman’s and Bartter’s syndromes, to inform the fight against COVID-19
Sign Up to like & getrecommendations! Published in 2021 at "Journal of Nephrology"
DOI: 10.1007/s40620-020-00951-6
Abstract: The COVID-19 pandemic has called enormous scientific attention to angiotensin converting enzyme 2 (ACE2) and other components of the renin-angiotensin system (RAS) since ACE2 plays a central role as the viral receptor initiating the SARS-CoV-2… read more here.
Keywords: infection; ace2; covid; ang ... See more keywords
A model for COVID-19-induced dysregulation of ACE2 shedding by ADAM17
Sign Up to like & getrecommendations! Published in 2021 at "Biochemical and Biophysical Research Communications"
DOI: 10.1016/j.bbrc.2021.08.040
Abstract: The angiotensin Converting Enzyme 2 (ACE2) receptor is a key component of the renin-angiotensin-aldesterone system (RAAS) that mediates numerous effects in the cardiovascular system. It is also the cellular point of contact for the coronavirus… read more here.
Keywords: model covid; induced dysregulation; ace2; shedding adam17 ... See more keywords
Repurposing of approved drugs with potential to interact with SARS-CoV-2 receptor
Sign Up to like & getrecommendations! Published in 2021 at "Biochemistry and Biophysics Reports"
DOI: 10.1016/j.bbrep.2021.100982
Abstract: Respiratory transmission is the primary route of Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) infection. Angiotensin I converting enzyme 2 (ACE2) is the known receptor of SARS-CoV-2 surface spike glycoprotein for entry into human cells.… read more here.
Keywords: interact; ace2; approved drugs; ace1 ... See more keywords
The angiotensin converting enzyme 2/angiotensin-(1-7)/Mas Receptor axis as a key player in alveolar bone remodeling.
Sign Up to like & getrecommendations! Published in 2019 at "Bone"
DOI: 10.1016/j.bone.2019.115041
Abstract: The renin-angiotensin system (RAS), aside its classical hormonal properties, has been implicated in the pathogenesis of inflammatory disorders. The angiotensin converting enzyme 2/angiotensin-(1-7)/Mas Receptor (ACE2/Ang-(1-7)/MasR) axis owns anti-inflammatory properties and was recently associated with bone… read more here.
Keywords: masr; ace2; bone; alveolar bone ... See more keywords
Should ACE2 be given a chance in COVID-19 therapeutics: A semi-systematic review of strategies enhancing ACE2
Sign Up to like & getrecommendations! Published in 2020 at "European Journal of Pharmacology"
DOI: 10.1016/j.ejphar.2020.173545
Abstract: The severe acute respiratory syndrome corona virus-2 (SARS-CoV-2) has resulted in almost 18 million cases of COVID-19 (Corona virus disease-2019) and more than 670000 deaths worldwide since December 2019. In the absence of effective antiviral… read more here.
Keywords: semi systematic; systematic review; ace2; covid ... See more keywords
Design of an engineered ACE2 as a novel therapeutics against COVID-19
Sign Up to like & getrecommendations! Published in 2020 at "Journal of Theoretical Biology"
DOI: 10.1016/j.jtbi.2020.110425
Abstract: Abstract The interaction between the angiotensin-converting enzyme 2 (ACE2) and the receptor binding domain (RBD) of the spike protein from severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) plays a pivotal role in virus entry into… read more here.
Keywords: engineered ace2; ace2; interaction; sars cov ... See more keywords
Diminazene aceturate extenuate the renal deleterious consequences of angiotensin-II induced by γ-irradiation through boosting ACE2 signaling cascade.
Sign Up to like & getrecommendations! Published in 2020 at "Life sciences"
DOI: 10.1016/j.lfs.2020.117749
Abstract: AIM This work aims to explore the role of diminazene aceturate (DIZE) in the enhancement of angiotensin-converting enzyme-2 (ACE2) to prevent the inflammatory and fibrotic response induced by γ-irradiation through activating the protective axis ACE2/angiotensin… read more here.
Keywords: renal deleterious; irradiation; diminazene aceturate; ace2 ... See more keywords