Targeting the Receptor-Binding Motif of SARS-CoV-2 with D-Peptides Mimicking the ACE2 Binding Helix: Lessons for Inhibiting Omicron and Future Variants of Concern
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Chemical Information and Modeling"
DOI: 10.1021/acs.jcim.2c00500
Abstract: The COVID-19 pandemic continues to spread around the world, with several new variants emerging, particularly those of concern (VOCs). Omicron (B.1.1.529), a recent VOC with many mutations in the spike protein’s receptor-binding domain (RBD), has… read more here.
Keywords: receptor binding; binding motif; targeting receptor; ace2 binding ... See more keywords
Constrained surfaces: promising therapeutic targets for COVID-19 determined by systematically mutational analysis
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DOI: 10.1038/s41392-021-00469-8
Abstract: A recent study published in Cell by Tyler N. Starr et al. presented a quantitative deep mutational scanning platform that allowed for the characterization of potential amino acid (AA) mutations to the SARS-CoV-2 receptor binding… read more here.
Keywords: sars cov; ace2 binding; rbd; binding affinity ... See more keywords
Omicron: Master of immune evasion maintains robust ACE2 binding
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DOI: 10.1038/s41392-022-00965-5
Abstract: The spike (S) protein of the SARS-CoV-2 Omicron variant is highly mutated but the impact of these mutations on viral entry into cells and its inhibition by antibodies has been unclear. A recent study published… read more here.
Keywords: omicron; robust ace2; ace2; evasion ... See more keywords
Comparative Magnitude and Persistence of Humoral SARS-CoV-2 Vaccination Responses in the Adult Population in Germany
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DOI: 10.3389/fimmu.2022.828053
Abstract: Recent increases in SARS-CoV-2 infections have led to questions about duration and quality of vaccine-induced immune protection. While numerous studies have been published on immune responses triggered by vaccination, these often focus on studying the… read more here.
Keywords: sars cov; vaccination; vector based; population ... See more keywords
Mutation-driven parallel evolution in emergence of ACE2-utilizing sarbecoviruses
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DOI: 10.3389/fmicb.2023.1118025
Abstract: Mutation and recombination are two major genetic mechanisms that drive the evolution of viruses. They both exert an interplay during virus evolution, in which mutations provide a first ancestral source of genetic diversity for subsequent… read more here.
Keywords: evolution; ace2 binding; mutation; sars cov ... See more keywords
Impact of SARS-CoV-2 RBM Mutations N501Y and E484K on ACE2 Binding: A Combined Computational and Experimental Study
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DOI: 10.3390/ijms26094064
Abstract: The SARS-CoV-2 spike receptor-binding motif is crucial for viral entry via interaction with the human ACE2 receptor. Mutations N501Y and E484K, found in several variants of concern, impact viral transmissibility and immune escape, but experimental… read more here.
Keywords: sars cov; ace2 binding; n501y e484k; mutations n501y ... See more keywords
Conformational dynamics and allosteric modulation of the SARS-CoV-2 spike
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DOI: 10.7554/elife.75433
Abstract: Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infects cells through binding to angiotensin-converting enzyme 2 (ACE2). This interaction is mediated by the receptor-binding domain (RBD) of the viral spike (S) glycoprotein. Structural and dynamic data… read more here.
Keywords: conformational dynamics; dynamics allosteric; ace2 binding; allosteric modulation ... See more keywords