Targeting the Receptor-Binding Motif of SARS-CoV-2 with D-Peptides Mimicking the ACE2 Binding Helix: Lessons for Inhibiting Omicron and Future Variants of Concern
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Chemical Information and Modeling"
DOI: 10.1021/acs.jcim.2c00500
Abstract: The COVID-19 pandemic continues to spread around the world, with several new variants emerging, particularly those of concern (VOCs). Omicron (B.1.1.529), a recent VOC with many mutations in the spike protein’s receptor-binding domain (RBD), has… read more here.
Keywords: receptor binding; binding motif; targeting receptor; ace2 binding ... See more keywords
Constrained surfaces: promising therapeutic targets for COVID-19 determined by systematically mutational analysis
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DOI: 10.1038/s41392-021-00469-8
Abstract: A recent study published in Cell by Tyler N. Starr et al. presented a quantitative deep mutational scanning platform that allowed for the characterization of potential amino acid (AA) mutations to the SARS-CoV-2 receptor binding… read more here.
Keywords: sars cov; ace2 binding; rbd; binding affinity ... See more keywords
Omicron: Master of immune evasion maintains robust ACE2 binding
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DOI: 10.1038/s41392-022-00965-5
Abstract: The spike (S) protein of the SARS-CoV-2 Omicron variant is highly mutated but the impact of these mutations on viral entry into cells and its inhibition by antibodies has been unclear. A recent study published… read more here.
Keywords: omicron; robust ace2; ace2; evasion ... See more keywords
Comparative Magnitude and Persistence of Humoral SARS-CoV-2 Vaccination Responses in the Adult Population in Germany
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DOI: 10.3389/fimmu.2022.828053
Abstract: Recent increases in SARS-CoV-2 infections have led to questions about duration and quality of vaccine-induced immune protection. While numerous studies have been published on immune responses triggered by vaccination, these often focus on studying the… read more here.
Keywords: sars cov; vaccination; vector based; population ... See more keywords
Mutation-driven parallel evolution in emergence of ACE2-utilizing sarbecoviruses
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DOI: 10.3389/fmicb.2023.1118025
Abstract: Mutation and recombination are two major genetic mechanisms that drive the evolution of viruses. They both exert an interplay during virus evolution, in which mutations provide a first ancestral source of genetic diversity for subsequent… read more here.
Keywords: evolution; ace2 binding; mutation; sars cov ... See more keywords
Conformational dynamics and allosteric modulation of the SARS-CoV-2 spike
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DOI: 10.7554/elife.75433
Abstract: Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infects cells through binding to angiotensin-converting enzyme 2 (ACE2). This interaction is mediated by the receptor-binding domain (RBD) of the viral spike (S) glycoprotein. Structural and dynamic data… read more here.
Keywords: conformational dynamics; dynamics allosteric; ace2 binding; allosteric modulation ... See more keywords