Akt‐independent effects of triciribine on ACE2 expression in human lung epithelial cells: Potential benefits in restricting SARS‐CoV2 infection
Sign Up to like & getrecommendations! Published in 2021 at "Journal of Cellular Physiology"
DOI: 10.1002/jcp.30343
Abstract: The severe acute respiratory syndrome coronavirus 2 that causes coronavirus disease 2019 (COVID‐19) binds to the angiotensin‐converting enzyme 2 (ACE2) to gain cellular entry. Akt inhibitor triciribine (TCBN) has demonstrated promising results in promoting recovery… read more here.
Keywords: epithelial cells; lung epithelial; ace2 expression; expression human ... See more keywords
Human pulmonary artery endothelial cells upregulate ACE2 expression in response to iron‐regulatory elements: potential implications for SARS‐CoV‐2 infection
Sign Up to like & getrecommendations! Published in 2022 at "Pulmonary Circulation"
DOI: 10.1002/pul2.12068
Abstract: Vascular endothelial cell dysfunction is reported in severe COVID-19 disease, however controversy exists regarding levels of ACE2 expression, a coreceptor for SarsCov2, in these cells. We report ACE2 expression and positive regulation by both IL-6,… read more here.
Keywords: pulmonary artery; ace2 expression; potential implications; artery endothelial ... See more keywords
Activation of the SARS-CoV-2 Receptor Ace2 through JAK/STAT-Dependent Enhancers during Pregnancy
Sign Up to like & getrecommendations! Published in 2020 at "Cell Reports"
DOI: 10.1016/j.celrep.2020.108199
Abstract: ACE2 binds the coronavirus SARS-CoV-2 and facilitates its cellular entry. Interferons activate ACE2 expression in pneumocytes, suggesting a critical role of cytokines in SARS-CoV-2 target cells. Viral RNA was detected in breast milk in at… read more here.
Keywords: sars cov; ace2 expression; jak stat;
Comparative analysis of SARS-CoV-2 receptor ACE2 expression in multiple solid tumors and matched non-diseased tissues
Sign Up to like & getrecommendations! Published in 2020 at "Infection, Genetics and Evolution"
DOI: 10.1016/j.meegid.2020.104428
Abstract: Abstract The emerging severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) poses a global public health emergency. SARS-CoV-2 employs the host cell receptor ACE2 for cellular entry. Nonetheless, the differences in ACE2 expression pattern in lung… read more here.
Keywords: ace2 expression; non diseased; receptor ace2; expression ... See more keywords
In Vitro and Silico Studies on the N-Doped Carbon Dots Potential in ACE2 Expression Modulation
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DOI: 10.1021/acsomega.2c07398
Abstract: The alteration of ACE2 expression level, which has been studied in many diseases, makes the topic of ACE2 inducer potential crucial to be explored. The ACE2 inducer could further be designed to control the ACE2… read more here.
Keywords: cell lines; carbon dots; ace2 expression; expression ... See more keywords
An ACE2 in the kidney
Sign Up to like & getrecommendations! Published in 2021 at "Nature Reviews Urology"
DOI: 10.1038/s41585-021-00439-3
Abstract: 0123456789();: Nature reviews | Urology ACE2 over expression in subcutaneous 786 O xeno grafts in mice delayed tumour formation Targeting the angiotensinconverting enzyme 2 (ACE2)–angiotensin (Ang)-(1–7) pathway could be a promising therapeutic strategy in clear… read more here.
Keywords: ace2 expression; treatment; expression; ang ... See more keywords
Smoking enhances the expression of angiotensin‐converting enzyme 2 involved in the efficiency of severe acute respiratory syndrome coronavirus 2 infection
Sign Up to like & getrecommendations! Published in 2022 at "Microbiology and Immunology"
DOI: 10.1111/1348-0421.13034
Abstract: Smoking is one of the risk factors most closely related to the severity of coronavirus disease 2019 (COVID‐19). However, the relationship between smoking history and severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2) infectivity is unknown.… read more here.
Keywords: coronavirus; expression; expression level; efficiency ... See more keywords
Individual variation of the SARS‐CoV‐2 receptor ACE2 gene expression and regulation
Sign Up to like & getrecommendations! Published in 2020 at "Aging Cell"
DOI: 10.1111/acel.13168
Abstract: The COVID‐19 coronavirus is now spreading worldwide. Its pathogen, SARS‐CoV‐2, has been shown to use angiotensin‐converting enzyme 2 (ACE2) as its host cell receptor, same as the severe acute respiratory syndrome coronavirus (SARS‐CoV) in 2003.… read more here.
Keywords: individual variation; variation sars; ace2 expression; expression ... See more keywords
Manipulation of ACE2 expression in COVID-19
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DOI: 10.1136/openhrt-2020-001424
Abstract: SARS-CoV-2 is the virus responsible for the ongoing COVID-19 outbreak. The virus uses ACE2 receptor for viral entry. ACE2 is part of the counter-regulatory renin-angiotensin-aldosterone system and is also expressed in the lower respiratory tract… read more here.
Keywords: manipulation ace2; expression covid; ace2 expression; expression ... See more keywords
Systematic identification of ACE2 expression modulators reveals cardiomyopathy as a risk factor for mortality in COVID-19 patients
Sign Up to like & getrecommendations! Published in 2022 at "Genome Biology"
DOI: 10.1186/s13059-021-02589-4
Abstract: Background Angiotensin-converting enzyme 2 (ACE2) is the cell-entry receptor for SARS-CoV-2. It plays critical roles in both the transmission and the pathogenesis of COVID-19. Comprehensive profiling of ACE2 expression patterns could reveal risk factors of… read more here.
Keywords: risk; expression; ace2 expression; covid patients ... See more keywords
ACE2 expression in saliva of patients with COVID-19 and its association with Candida albicans and Aggregatibacter actinomycetemcomitans
Sign Up to like & getrecommendations! Published in 2022 at "F1000Research"
DOI: 10.12688/f1000research.111965.2
Abstract: Background: A relationship between oral microbiota and susceptibility to SARS-CoV-2 infection has been extensively studied. However, the relationship between oral commensal flora and expression of angiotensin-converting enzyme 2 ( ACE2) remains to be established. In… read more here.
Keywords: relationship; expression; saliva patients; patients covid ... See more keywords