Evidence for an ACE2-Independent Entry Pathway That Can Protect from Neutralization by an Antibody Used for COVID-19 Therapy
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DOI: 10.1128/mbio.00364-22
Abstract: The interaction of the SARS-CoV-2 spike protein (S) with the cellular receptor ACE2 is considered essential for infection and constitutes the key target for antibodies induced upon infection and vaccination. Here, using a surrogate system… read more here.
Keywords: entry; sars cov; ace2 independent; antibody ... See more keywords
ACE2-Independent Bat Sarbecovirus Entry and Replication in Human and Bat Cells
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DOI: 10.1128/mbio.02566-22
Abstract: Our studies demonstrate that some unexplored sarbecoviruses are capable of replicating in human and bat cells in an ACE2-independent way but need a high trypsin environment. We found that trypsin is not compensated by other… read more here.
Keywords: human bat; trypsin; entry; bat cells ... See more keywords
ACE2-Independent Alternative Receptors for SARS-CoV-2
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DOI: 10.3390/v14112535
Abstract: Severe acute respiratory syndrome-related coronavirus (SARS-CoV-2), the causative agent of coronavirus disease 2019 (COVID-19), is highly contagious and remains a major public health challenge despite the availability of effective vaccines. SARS-CoV-2 enters cells through the… read more here.
Keywords: entry; independent alternative; receptors sars; ace2 independent ... See more keywords