Probing structural basis for enhanced binding of SARS‐CoV‐2 P.1 variant spike protein with the human ACE2 receptor
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Cellular Biochemistry"
DOI: 10.1002/jcb.30276
Abstract: The initial step of infection by severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2) involves the binding of receptor binding domain (RBD) of the spike protein to the angiotensin converting enzyme 2 (ACE2) receptor. Each successive… read more here.
Keywords: ace2 receptor; sars cov; receptor; spike protein ... See more keywords
Different compounds against Angiotensin-Converting Enzyme 2 (ACE2) receptor potentially containing the infectivity of SARS-CoV-2: an in silico study
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Molecular Modeling"
DOI: 10.1007/s00894-022-05059-1
Abstract: Novel SARS coronavirus or SARS-CoV-2 is a novel coronavirus that was identified and spread from Wuhan in 2019. On January 30th, the World Health Organization declared the coronavirus outbreak as a Global Public Health Emergency.… read more here.
Keywords: study; sars cov; luteolin chrysin; ace2 receptor ... See more keywords
Molecular docking suggests repurposing of brincidofovir as a potential drug targeting SARS-CoV-2 ACE2 receptor and main protease
Sign Up to like & getrecommendations! Published in 2020 at "Network Modeling and Analysis in Health Informatics and Bioinformatics"
DOI: 10.1007/s13721-020-00263-6
Abstract: Abstract The current outbreak of the highly transmittable and life-threatening severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has evolved rapidly and posed a global health emergency. Many clinical trials are now being conducted to test… read more here.
Keywords: protease; cov ace2; ace2 receptor; sars cov ... See more keywords
How tetraspanin-mediated cell entry of SARS-CoV-2 can dysregulate the shedding of the ACE2 receptor by ADAM17
Sign Up to like & getrecommendations! Published in 2022 at "Biochemical and Biophysical Research Communications"
DOI: 10.1016/j.bbrc.2022.01.038
Abstract: COVID-19, the respiratory infection caused by the novel coronavirus SARS-CoV-2, presents a clinical picture consistent with the dysregulation of many of the pathways mediated by the metalloprotease ADAM17. ADAM17 is a sheddase that plays a… read more here.
Keywords: sars cov; adam17; cell entry; ace2 receptor ... See more keywords
Characteristics Associated with Serological Covid-19 Vaccine Response and Durability in an Older Population with Significant Comorbidity: The Danish Nationwide ENFORCE Study
Sign Up to like & getrecommendations! Published in 2022 at "Clinical Microbiology and Infection"
DOI: 10.1016/j.cmi.2022.03.003
Abstract: Objectives To identify individual characteristics associated with serological COVID-19 vaccine responsiveness and durability of vaccine-induced antibodies. Methods Adults without history of SARS-CoV-2 infection from the Danish population scheduled for SARS-CoV-2 vaccination were enrolled in this… read more here.
Keywords: response; spike ace2; vaccine; ace2 receptor ... See more keywords
Anti-SARS-CoV-2 immunoglobulin profile in patients with celiac disease living in a high incidence area
Sign Up to like & getrecommendations! Published in 2021 at "Digestive and Liver Disease"
DOI: 10.1016/j.dld.2021.08.027
Abstract: Background and aim How symptoms and antibodies related to SARS-CoV-2 infection develop in patients with celiac disease (CD) is unclear. We aimed to investigate the impact of SARS-CoV-2 infection in CD patients. Methods CD patients… read more here.
Keywords: patients celiac; celiac disease; ace2 receptor; anti sars ... See more keywords
Direct or indirect endothelial damage? An unresolved question
Sign Up to like & getrecommendations! Published in 2021 at "EBioMedicine"
DOI: 10.1016/j.ebiom.2021.103215
Abstract: In this article in EBioMedicine, Zsuzsanna Varga and colleagues [1] published an immunohistochemistry-based study for the presence of ACE2 receptor, T-cell markers, and macrophage markers, in different anatomical regions of the coronary tree of six… read more here.
Keywords: question direct; direct indirect; ace2 receptor; damage ... See more keywords
A molecular docking study revealed that synthetic peptides induced conformational changes in the structure of SARS-CoV-2 spike glycoprotein, disrupting the interaction with human ACE2 receptor
Sign Up to like & getrecommendations! Published in 2020 at "International Journal of Biological Macromolecules"
DOI: 10.1016/j.ijbiomac.2020.07.174
Abstract: Abstract The global outbreak of COVID-19 (Coronavirus Disease 2019) caused by SARS-CoV-2 (Severe Acute Respiratory Syndrome caused by Coronavirus 2) began in December 2019. Its closest relative, SARS-CoV-1, has a slightly mutated Spike (S) protein,… read more here.
Keywords: synthetic peptides; ace2 receptor; spike; interaction ... See more keywords
Effect of an Inhibitor on the ACE2-Receptor-Binding Domain of SARS-CoV-2
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Chemical Information and Modeling"
DOI: 10.1021/acs.jcim.1c01283
Abstract: The recent outbreak of COVID-19 infection started in Wuhan, China, and spread across China and beyond. Since the WHO declared COVID-19 a pandemic (March 11, 2020), three vaccines and only one antiviral drug (remdesivir) have… read more here.
Keywords: receptor binding; inhibitor; ace2 receptor; binding domain ... See more keywords
Engineered ACE2 receptor therapy overcomes mutational escape of SARS-CoV-2
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DOI: 10.1038/s41467-021-24013-y
Abstract: SARS-CoV-2 has mutated during the global pandemic leading to viral adaptation to medications and vaccinations. Here we describe an engineered human virus receptor, ACE2, by mutagenesis and screening for binding to the receptor binding domain… read more here.
Keywords: escape; ace2 receptor; receptor therapy; sars cov ... See more keywords
Human Air-Liquid-Interface Organotypic Airway Cultures Express Significantly More ACE2 Receptor Protein and Are More Susceptible to HCoV-NL63 Infection than Monolayer Cultures of Primary Respiratory Epithelial Cells
Sign Up to like & getrecommendations! Published in 2022 at "Microbiology Spectrum"
DOI: 10.1128/spectrum.01639-22
Abstract: HCoV-NL63 is widespread globally, accounting for a significant number of respiratory infections in children and adults. HCoV-NL63 gains entrance into respiratory epithelial cells via the ACE2 receptor, the same cell receptor used by severe acute… read more here.
Keywords: ace2 receptor; infection; hcov nl63; nl63 infection ... See more keywords