Analysis of ACE2 and TMPRSS2 coding variants as a risk factor for SARS‐CoV‐2 from 946 whole‐exome sequencing data in the Turkish population
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Medical Virology"
DOI: 10.1002/jmv.27976
Abstract: Heterogeneity in symptoms associated with COVID‐19 in infected patients remains unclear. ACE2 and TMPRSS2 gene variants are considered possible risk factors for COVID‐19. In this study, a retrospective comparative genome analysis of the ACE2 and… read more here.
Keywords: turkish population; ace2 tmprss2; sars cov;
Co-expression of the SARS-CoV-2 entry receptors ACE2 and TMPRSS2 in healthy human conjunctiva
Sign Up to like & getrecommendations! Published in 2021 at "Experimental Eye Research"
DOI: 10.1016/j.exer.2021.108527
Abstract: The purpose of this study was to evaluate the expression of the SARS-CoV-2 receptors ACE2 and TMPRSS2 in an immortalized human conjunctival epithelial cell line and in healthy human conjunctiva excised during ocular surgery, using… read more here.
Keywords: microscopy; ace2 tmprss2; expression; conjunctival ... See more keywords
PFOA induces alteration in DNA methylation regulators and SARS-CoV-2 targets Ace2 and Tmprss2 in mouse lung tissues
Sign Up to like & getrecommendations! Published in 2021 at "Toxicology Reports"
DOI: 10.1016/j.toxrep.2021.11.014
Abstract: Perfluorooctanoic acid (PFOA), a ubiquitous environmental toxicant from the Per- and polyfluoroalkyl substances (PFAS) family has been implicated in toxicity of various organs. Several epidemiological studies have linked PFOA to different lung injuries and diseased… read more here.
Keywords: sars cov; dna methylation; ace2 tmprss2; pfoa ... See more keywords
Well-differentiated liver cancers reveal the potential link between ACE2 dysfunction and metabolic breakdown
Sign Up to like & getrecommendations! Published in 2022 at "Scientific Reports"
DOI: 10.1038/s41598-021-03710-0
Abstract: Angiotensin-converting enzyme 2 (ACE2) is the receptor of the Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) causing Coronavirus disease 2019 (COVID-19). Transmembrane serine protease 2 (TMPRSS2) is a coreceptor. Abnormal hepatic function in COVID-19 suggests… read more here.
Keywords: dysfunction metabolic; metabolic breakdown; ace2 tmprss2; liver cancers ... See more keywords
PCIF1-mediated deposition of 5′-cap N6,2′-O-dimethyladenosine in ACE2 and TMPRSS2 mRNA regulates susceptibility to SARS-CoV-2 infection
Sign Up to like & getrecommendations! Published in 2023 at "Proceedings of the National Academy of Sciences of the United States of America"
DOI: 10.1073/pnas.2210361120
Abstract: Significance Understanding the molecular mechanisms of SARS-CoV-2 viral pathogenesis and developing novel inhibitors are essential and urgent. Using genome-wide N6,2′-O-dimethyladenosine (m6Am)-exo-seq, RNA-seq analysis, and CRISPR/Cas9 genome editing, we discovered that phosphorylated CTD-interacting factor 1 (PCIF1),… read more here.
Keywords: infection; pcif1; cap; ace2 tmprss2 ... See more keywords
Sex and diet, but not exercise, alter cardiovascular ACE2 and TMPRSS2 mRNA levels in aortic banded swine
Sign Up to like & getrecommendations! Published in 2023 at "Journal of Applied Physiology"
DOI: 10.1152/japplphysiol.00736.2022
Abstract: SARS-COV-2, or COVID-19, is a respiratory virus that enters tissues via the angiotensin-converting enzyme 2 (ACE2) receptor and is primed and activated by transmembrane protease, serine 2 (TMPRSS2). An interesting dichotomy exists regarding the preventative/therapeutic… read more here.
Keywords: tmprss2 mrna; aortic banded; sex; ace2 tmprss2 ... See more keywords
Age and gender differences in ACE2 and TMPRSS2 expressions in oral epithelial cells
Sign Up to like & getrecommendations! Published in 2021 at "Journal of Translational Medicine"
DOI: 10.1186/s12967-021-03037-4
Abstract: Background SARS-CoV-2, which has brought a huge negative impact on the world since the end of 2019, is reported to invade cells using the spike (S) protein to bind to angiotensin-converting enzyme II (ACE2) receptors… read more here.
Keywords: epithelial cells; ace2 tmprss2; age gender; sars cov ... See more keywords
Exercise-induced myokines downregulates the ACE2 level in bronchial epithelial cells: Implications for SARS-CoV-2 prevention
Sign Up to like & getrecommendations! Published in 2022 at "PLoS ONE"
DOI: 10.1371/journal.pone.0271303
Abstract: Background The Covid-19 pandemic has emerged as the leading public health challenge of our time (20th century). While vaccinations have finally blunted the death rate, concern has remained about more virulent forms highlighting the need… read more here.
Keywords: cell; induced myokines; exercise induced; ace2 tmprss2 ... See more keywords
Distinct spatial arrangements of ACE2 and TMPRSS2 expression in Syrian hamster lung lobes dictates SARS-CoV-2 infection patterns
Sign Up to like & getrecommendations! Published in 2022 at "PLoS Pathogens"
DOI: 10.1371/journal.ppat.1010340
Abstract: SARS-CoV-2 attaches to angiotensin-converting enzyme 2 (ACE2) to gain entry into cells after which the spike protein is cleaved by the transmembrane serine protease 2 (TMPRSS2) to facilitate viral-host membrane fusion. ACE2 and TMPRSS2 expression… read more here.
Keywords: tmprss2 expression; infection; expression; syrian hamster ... See more keywords
Cellular Tropism of SARS-CoV-2 across Human Tissues and Age-related Expression of ACE2 and TMPRSS2 in Immune-inflammatory Stromal Cells
Sign Up to like & getrecommendations! Published in 2021 at "Aging and Disease"
DOI: 10.14336/ad.2021.0429
Abstract: Recently, emerging evidence has indicated that COVID-19 represents a major threat to older populations, but the underlying mechanisms remain unclear. The pathogen causing COVID-19 is acute respiratory syndrome coronavirus 2 (SARS-CoV-2). SARS-CoV-2 infection depends on… read more here.
Keywords: ace2 tmprss2; tropism; age related; sars cov ... See more keywords
Soluble ACE2 and TMPRSS2 Levels in the Serum of Asthmatic Patients
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Korean Medical Science"
DOI: 10.3346/jkms.2022.37.e65
Abstract: Background Angiotensin-converting enzyme 2 (ACE2) and transmembrane protease serine subtype 2 (TMPRSS2) are key proteins mediating viral entry of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Although gene expressions of ACE2 and TMPRSS2 have been… read more here.
Keywords: levels serum; asthmatic patients; soluble ace2; tmprss2 levels ... See more keywords