Age-specific effectiveness following each dose of acellular pertussis vaccine among infants and children in New Zealand.
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DOI: 10.1016/j.vaccine.2016.11.004
Abstract: BACKGROUND Though it is believed the switch from whole cell to acellular pertussis vaccine has contributed to the resurgence of pertussis disease, few studies have evaluated vaccine effectiveness (VE) and duration of protection provided by… read more here.
Keywords: new zealand; age; acellular pertussis; pertussis vaccine ... See more keywords
Extensive swelling of the limb and systemic symptoms after a fourth dose of acellular pertussis containing vaccines in England in children aged 3-6years.
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DOI: 10.1016/j.vaccine.2016.12.017
Abstract: Extensive limb swelling (ESL) after a booster dose of acellular pertussis (aP) containing vaccine can cause concern and has the potential to be confused with cellulitis. In the United Kingdom aP-containing vaccine was introduced for… read more here.
Keywords: fourth dose; acellular pertussis; ipv; pertussis containing ... See more keywords
Addition of a TLR7 agonist to an acellular pertussis vaccine enhances Th1 and Th17 responses and protective immunity in a mouse model.
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DOI: 10.1016/j.vaccine.2017.08.009
Abstract: A resurgence of whooping cough (pertussis) has been observed in recent years in a number of developed countries, despite widespread vaccine coverage. Although the exact reasons of the recurrence of pertussis are not clear, there… read more here.
Keywords: vaccine; acellular pertussis; th1 th17; pertussis ... See more keywords
Suppression of mucosal Th17 memory responses by acellular pertussis vaccines enhances nasal Bordetella pertussis carriage
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DOI: 10.1038/s41541-020-00270-8
Abstract: Pertussis has made a spectacular rebound in countries that have switched from whole-cell (wPV) to acellular pertussis vaccines (aPV). Here, we show that, unlike wPV, aPV, while protective against lung colonization by Bordetella pertussis (Bp),… read more here.
Keywords: memory; pertussis vaccines; acellular pertussis; bordetella pertussis ... See more keywords
Novel approaches to reactivate pertussis immunity
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DOI: 10.1080/14760584.2022.2149499
Abstract: ABSTRACT Introduction Whole cell and acellular pertussis vaccines have been very effective in decreasing the deaths of neonates and infants from Bordetella pertussis. Despite high vaccine coverage worldwide, pertussis remains one of the most common… read more here.
Keywords: approaches reactivate; acellular pertussis; novel approaches; pertussis vaccines ... See more keywords
Acellular pertussis vaccines effectiveness over time: A systematic review, meta-analysis and modeling study
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DOI: 10.1371/journal.pone.0197970
Abstract: Background Acellular pertussis vaccine studies postulate that waning protection, particularly after the adolescent booster, is a major contributor to the increasing US pertussis incidence. However, these studies reported relative (ie, vs a population given prior… read more here.
Keywords: booster; acellular pertussis; time; pertussis vaccine ... See more keywords
Safety Surveillance of Diphtheria and Tetanus Toxoids and Acellular Pertussis (DTaP) Vaccines
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DOI: 10.1542/peds.2017-4171
Abstract: Post-marketing surveillance of DTaP vaccines was conducted in VAERS over a 19 year period to assess for possible rare AEs not detected in observational studies. OBJECTIVE: To assess the safety of currently licensed diphtheria-tetanus-acellular pertussis… read more here.
Keywords: dtap; surveillance; acellular pertussis; diphtheria tetanus ... See more keywords
Systemic priming and intranasal booster with a BcfA-adjuvanted acellular pertussis vaccine generates CD4+ IL-17+ nasal tissue resident T cells and reduces B. pertussis nasal colonization
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DOI: 10.3389/fimmu.2023.1181876
Abstract: Introduction Resurgence of pertussis, caused by Bordetella pertussis, necessitates novel vaccines and vaccination strategies to combat this disease. Alum-adjuvanted acellular pertussis vaccines (aPV) delivered intramuscularly reduce bacterial numbers in the lungs of immunized animals and… read more here.
Keywords: colonization; acellular pertussis; bcfa; nasal colonization ... See more keywords
Evaluation of Whole-Cell and Acellular Pertussis Vaccines in the Context of Long-Term Herd Immunity
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DOI: 10.3390/vaccines11010001
Abstract: After the pertussis vaccine had been introduced in the 1940s and was shown to be very successful in reducing the morbidity and mortality associated with the disease, the possibility of improving both vaccine composition and… read more here.
Keywords: cell acellular; acellular pertussis; whole cell; pertussis vaccines ... See more keywords
Acellular Pertussis Vaccine Components: Today and Tomorrow
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DOI: 10.3390/vaccines8020217
Abstract: Pertussis is a highly communicable acute respiratory infection caused by Bordetella pertussis. Immunity is not lifelong after natural infection or vaccination. Pertussis outbreaks occur cyclically worldwide and effective vaccination strategies are needed to control disease.… read more here.
Keywords: vaccine components; acellular pertussis; components today; pertussis vaccine ... See more keywords
Tetanus–diphtheria–acellular pertussis vaccination for adults: an update
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DOI: 10.7774/cevr.2017.6.1.22
Abstract: Although tetanus and diphtheria have become rare in developed countries, pertussis is still endemic in some developed countries. These are vaccine-preventable diseases and vaccination for adults is important to prevent the outbreak of disease. Strategies… read more here.
Keywords: pertussis; diphtheria acellular; acellular pertussis; tetanus diphtheria ... See more keywords