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Published in 2022 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms23031037
Abstract: Inhibition of the human O-linked β-N-acetylglucosaminidase (hOGA, GH84) enzyme is pharmacologically relevant in several diseases such as neurodegenerative and cardiovascular disorders, type 2 diabetes, and cancer. Human lysosomal hexosaminidases (hHexA and hHexB, GH20) are mechanistically…
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Keywords:
glucono lactone;
lactone;
acetamido deoxy;
deoxy glucono ... See more keywords
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Published in 2021 at "Molecules"
DOI: 10.3390/molecules26195883
Abstract: O-GlcNAcylation is a nutrient-driven post-translational modification known as a metabolic sensor that links metabolism to cellular function. Recent evidences indicate that the activation of O-GlcNAc pathway is a potential pro-survival pathway and that acute enhancement…
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Keywords:
mitochondrial network;
acetamido deoxy;
glcnacylation;
ethyl acetamido ... See more keywords