Alcohol, Fasting, and Therapeutic Dosing of Acetaminophen: A Perfect Storm
Sign Up to like & getrecommendations! Published in 2021 at "Hepatology"
DOI: 10.1002/hep.31747
Abstract: Acetaminophen (paracetamol, APAP) remains an ongoing public health problem more than 50 years after its introduction in the United Kingdom (UK) in the 1960's. Despite the presence of a highly effective antidote, N-acetylcysteine, APAP toxicity… read more here.
Keywords: acetaminophen perfect; therapeutic dosing; acetaminophen; dosing acetaminophen ... See more keywords
Real-World Hepatic Safety of Oral Acetaminophen versus Loxoprofen/Celecoxib: Using a Nationwide Electronic Medical Record Database.
Sign Up to like & getrecommendations! Published in 2023 at "Journal of clinical pharmacology"
DOI: 10.1002/jcph.2216
Abstract: The aim of this study was to investigate the incidence of liver injury associated with acetaminophen compared with commonly prescribed two non-steroidal anti-inflammatory drugs, loxoprofen and celecoxib, over one-year period. This study used an electronic… read more here.
Keywords: celecoxib; liver injury; loxoprofen celecoxib; electronic medical ... See more keywords
Intravenous vs oral acetaminophen in sinus surgery: A randomized clinical trial
Sign Up to like & getrecommendations! Published in 2020 at "Laryngoscope Investigative Otolaryngology"
DOI: 10.1002/lio2.375
Abstract: Multimodal perioperative analgesia including acetaminophen is recommended by current guidelines. The comparative efficacy of intravenous vs oral acetaminophen in sinus surgery is unknown. We aimed to determine whether intravenous or oral acetaminophen results in superior… read more here.
Keywords: acetaminophen; intravenous oral; oral acetaminophen; sinus surgery ... See more keywords
Assessment of Sucralose, Caffeine and Acetaminophen as Anthropogenic Tracers in Aquatic Systems Across Florida
Sign Up to like & getrecommendations! Published in 2020 at "Bulletin of Environmental Contamination and Toxicology"
DOI: 10.1007/s00128-020-02942-6
Abstract: Sucralose is one of the most popular artificial sweeteners worldwide. Due to its high stability, persistence and low removal efficiency in wastewater treatment plants, sucralose has been used as an indicator of wastewater intrusion into… read more here.
Keywords: aquatic systems; acetaminophen; caffeine; tracers aquatic ... See more keywords
DAMPs and sterile inflammation in drug hepatotoxicity
Sign Up to like & getrecommendations! Published in 2018 at "Hepatology International"
DOI: 10.1007/s12072-018-9911-9
Abstract: Drug hepatotoxicity is the leading cause of acute liver failure (ALF) in the developed countries. The early diagnosis and treatment are still problematic, and one important reason is the lack of reliable mechanistic biomarkers and… read more here.
Keywords: phase; drug hepatotoxicity; acetaminophen; sterile inflammation ... See more keywords
Acetaminophen (Paracetamol) Induces Hypothermia During Acute Cold Stress
Sign Up to like & getrecommendations! Published in 2017 at "Clinical Drug Investigation"
DOI: 10.1007/s40261-017-0560-x
Abstract: BackgroundAcetaminophen is an over-the-counter drug used to treat pain and fever, but it has also been shown to reduce core temperature (Tc) in the absence of fever. However, this side effect is not well examined… read more here.
Keywords: acute cold; acetaminophen; exposure; min ... See more keywords
Integration of Placental Transfer in a Fetal–Maternal Physiologically Based Pharmacokinetic Model to Characterize Acetaminophen Exposure and Metabolic Clearance in the Fetus
Sign Up to like & getrecommendations! Published in 2020 at "Clinical Pharmacokinetics"
DOI: 10.1007/s40262-020-00861-7
Abstract: Background and Objective Although acetaminophen is frequently used during pregnancy, little is known about fetal acetaminophen pharmacokinetics. Acetaminophen safety evaluation has typically focused on hepatotoxicity, while other events (fetal ductal closure/constriction) are also relevant. We… read more here.
Keywords: acetaminophen; placental transfer; model; acetaminophen exposure ... See more keywords
Pain management using acetaminophen throughout postoperative course of laparoscopic colorectal surgery: A case-matched control study
Sign Up to like & getrecommendations! Published in 2017 at "Annals of Medicine and Surgery"
DOI: 10.1016/j.amsu.2017.03.033
Abstract: Backgroud The main advantage of laparoscopic surgery is that it is minimally invasive because of the use of small incisions. An approach using small incisions offers many benefits including attenuation of surgical wound pain. However,… read more here.
Keywords: surgery; acetaminophen; pain management; postoperative pain ... See more keywords
A Randomized Trial Comparing the Efficacy of Five Oral Analgesics for Treatment of Acute Musculoskeletal Extremity Pain in the Emergency Department.
Sign Up to like & getrecommendations! Published in 2020 at "Annals of emergency medicine"
DOI: 10.1016/j.annemergmed.2020.10.004
Abstract: STUDY OBJECTIVE We compare the efficacy and adverse effects of 5 oral analgesics in emergency department (ED) patients aged 21 to 64 years with acute musculoskeletal pain. METHODS This was a randomized clinical trial conducted… read more here.
Keywords: 000 acetaminophen; acetaminophen; patients receiving; ibuprofen 000 ... See more keywords
Acute acetaminophen intoxication induces direct neurotoxicity in rats manifested as astrogliosis and decreased dopaminergic markers in brain areas associated with locomotor regulation.
Sign Up to like & getrecommendations! Published in 2019 at "Biochemical Pharmacology"
DOI: 10.1016/j.bcp.2019.113662
Abstract: Abstract Acetaminophen (APAP) administration at therapeutic doses is safe, however overdosing produces hepatocellular injury via a multifactorial mechanism(s) that involves generation of reactive oxygen species (ROS), being the most common cause of acute liver failure… read more here.
Keywords: intoxication; astrogliosis; brain areas; acute ... See more keywords
Performance study on adsorptive removal of acetaminophen from wastewater using silica microspheres: Kinetic and isotherm studies
Sign Up to like & getrecommendations! Published in 2021 at "Chemosphere"
DOI: 10.1016/j.chemosphere.2021.129896
Abstract: Abstract Owing to the global industrialization, a new generation of pharmaceutical pollutants with high toxicity and persistency have been detected. In the present study, silica microspheres, a promising adsorbent has been employed to investigate the… read more here.
Keywords: wastewater; removal; study; adsorption ... See more keywords