Evaluation of urinary acetaminophen metabolites and its association with the genetic polymorphisms of the metabolising enzymes, and serum acetaminophen concentrations in preterm neonates with patent ductus arteriosus
Sign Up to like & getrecommendations! Published in 2021 at "Xenobiotica"
DOI: 10.1080/00498254.2021.1982070
Abstract: Abstract Acetaminophen is gaining importance as a first-line drug for treating patent ductus arteriosus (PDA) in neonates. Predominant metabolites of acetaminophen in preterm neonates vary from that of adults; and the drug is predominantly metabolised… read more here.
Keywords: preterm neonates; acetaminophen; ductus arteriosus; acetaminophen concentrations ... See more keywords
Comment on: “population pharmacokinetic analysis of acetaminophen overdose with immediate release, extended release and modified release formulations”
Sign Up to like & getrecommendations! Published in 2022 at "Clinical Toxicology"
DOI: 10.1080/15563650.2022.2135519
Abstract: We read with interest the work by Spyker et al., that simulated overdose of different acetaminophen formulations [1]. We compare their model of 100 g MR preparations in overdose, to actual acetaminophen concentrations of MR… read more here.
Keywords: acetaminophen overdose; acetaminophen concentrations; overdose patients; release ... See more keywords