C-reactive protein protects against acetaminophen-induced liver injury by preventing complement overactivation.
Sign Up to like & getrecommendations! Published in 2021 at "Cellular and molecular gastroenterology and hepatology"
DOI: 10.1016/j.jcmgh.2021.09.003
Abstract: BACKGROUND AND AIMS C-reactive protein (CRP) is a hepatocyte-produced marker of inflammation yet with undefined function in liver injury. We aimed to examine the role of CRP in acetaminophen-induced liver injury (AILI). METHODS The effects… read more here.
Keywords: crp; induced liver; reactive protein; acetaminophen induced ... See more keywords
The Chrysin effect in prevention of acetaminophen-induced hepatotoxicity in rat.
Sign Up to like & getrecommendations! Published in 2019 at "Chemical research in toxicology"
DOI: 10.1021/acs.chemrestox.9b00332
Abstract: Acetaminophen is a commonly used analgesic drug that induces hepatotoxicity at high doses and produces the acetaminophen metabolite N-acetyl-p-benzoquinone imine (NAPQI) through oxidase isoenzyme system. The anti-oxidant and anti-inflammatory activity of flavonoid chrysin has been… read more here.
Keywords: effect; chrysin; acetaminophen induced; induced hepatotoxicity ... See more keywords
Hepatoprotective effect of essential oils of Nepeta cataria L. on acetaminophen-induced liver dysfunction
Sign Up to like & getrecommendations! Published in 2019 at "Bioscience Reports"
DOI: 10.1042/bsr20190697
Abstract: Abstract Nepeta cataria L. has long been used in folk food and medicine for several functions. Essential oils (EOs) were extracted from Nepeta cataria L. by supercritical fluid extraction. The results of animal experiments showed… read more here.
Keywords: induced liver; effect essential; nepeta cataria; hepatoprotective effect ... See more keywords
Therapeutic Potential of Isorhamnetin following Acetaminophen-Induced Hepatotoxicity through Targeting NLRP3/NF-κB/Nrf2.
Sign Up to like & getrecommendations! Published in 2022 at "Drug research"
DOI: 10.1055/a-1792-2678
Abstract: Acetaminophen (APAP)-induced acute liver injury (ALI) is the principal cause of acute liver failure (ALF) in some countries including the United States and with few available treatments. Isorhamnetin is a bioflavonoid that is found in… read more here.
Keywords: acetaminophen induced; stress inflammation; acetaminophen; oxidative stress ... See more keywords
Acetaminophen induced methemoglobinemia
Sign Up to like & getrecommendations! Published in 2019 at "Clinical Toxicology"
DOI: 10.1080/15563650.2019.1677909
Abstract: To the Editor,We read with interest the recent article by Rianprakaisang et al. and have the following additional comments and questions regarding acetaminophen-induced methemoglobinemia [1].As men... read more here.
Keywords: acetaminophen induced; induced methemoglobinemia; toxicology;
Glycycoumarin protects mice against acetaminophen‐induced liver injury predominantly via activating sustained autophagy
Sign Up to like & getrecommendations! Published in 2018 at "British Journal of Pharmacology"
DOI: 10.1111/bph.14444
Abstract: Acetaminophen‐induced acute liver injury (AILI) is the most frequent cause of acute liver failure in developed countries. Given the significant limitations associated with N‐acetyl cysteine, the only antidote used to treat AILI, the development of… read more here.
Keywords: liver injury; glycycoumarin protects; protects mice; acetaminophen induced ... See more keywords
Ficus exasperata Attenuates Acetaminophen-Induced Hepatic Damage via NF-κB Signaling Mechanism in Experimental Rat Model
Sign Up to like & getrecommendations! Published in 2022 at "BioMed Research International"
DOI: 10.1155/2022/6032511
Abstract: Ficus exasperata has been used to treat ulcer, diabetes, fever, and a variety of stress-related disorders. Acetaminophen (APAP) overdose is the most common cause of drug-induced acute liver injury. In this study, we evaluated the… read more here.
Keywords: ficus exasperata; acetaminophen induced; exasperata; control group ... See more keywords
Hepatoprotective Role of α-Lipoic acid and Thymoquinone in Acetaminophen- Induced Liver Injury: Down-Regulation of COX-2 and flt-1 Expression
Sign Up to like & getrecommendations! Published in 2017 at "Brazilian Archives of Biology and Technology"
DOI: 10.1590/1678-4324-2017160703
Abstract: ABSTRACT Acetaminophen (APAP) is a widely-used analgesic, while toxic doses of which induce liver injury. Inducible cyclooxygenase-2 (COX-2) is derived prostaglandins which play an anti-inflammatory role in acetaminophen-induced hepatotoxicity. Selective activation of vascular endothelial growth… read more here.
Keywords: liver injury; cox flt; injury; acetaminophen induced ... See more keywords
Protective Effects of Apamin on Acetaminophen-Induced Hepatotoxicity in Mice
Sign Up to like & getrecommendations! Published in 2023 at "Current Issues in Molecular Biology"
DOI: 10.3390/cimb45050279
Abstract: Acetaminophen (APAP) overdose can cause severe liver damage, but therapeutic options are limited. Apamin is a natural peptide present in bee venom and has antioxidant and anti-inflammatory properties. Accumulating evidence suggests that apamin has favorable… read more here.
Keywords: protective effects; apamin; apamin acetaminophen; acetaminophen induced ... See more keywords
Dietary α-Mangostin Provides Protective Effects against Acetaminophen-Induced Hepatotoxicity in Mice via Akt/mTOR-Mediated Inhibition of Autophagy and Apoptosis
Sign Up to like & getrecommendations! Published in 2018 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms19051335
Abstract: Acetaminophen overdose-induced hepatotoxicity is the most common cause of acute liver failure in many countries. Previously, alpha-mangostin (α-MG) has been confirmed to exert protective effects on a variety of liver injuries, but the protective effect… read more here.
Keywords: acetaminophen induced; induced hepatotoxicity; mice; mtor ... See more keywords
Acetaminophen-Induced Liver Injury Exposes Murine IL-22 as Sex-Related Gene Product
Sign Up to like & getrecommendations! Published in 2021 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms221910623
Abstract: Gaining detailed knowledge about sex-related immunoregulation remains a crucial prerequisite for the development of adequate disease models and therapeutic strategies enabling personalized medicine. Here, the key parameter of the production of cytokines mediating disease resolution… read more here.
Keywords: induced liver; acetaminophen induced; sex related; liver injury ... See more keywords