Acetate Promotes T Cell Effector Function during Glucose Restriction.
Sign Up to like & getrecommendations! Published in 2019 at "Cell reports"
DOI: 10.1016/j.celrep.2019.04.022
Abstract: Competition for nutrients like glucose can metabolically restrict T cells and contribute to their hyporesponsiveness during cancer. Metabolic adaptation to the surrounding microenvironment is therefore key for maintaining appropriate cell function. For instance, cancer cells use… read more here.
Keywords: function glucose; effector function; promotes cell; function ... See more keywords
Gut-derived acetate promotes B10 cells with antiinflammatory effects
Sign Up to like & getrecommendations! Published in 2021 at "JCI Insight"
DOI: 10.1172/jci.insight.144156
Abstract: Autoimmune diseases are characterized by a breakdown of immune tolerance partly due to environmental factors. The short-chain fatty acid acetate, derived mostly from gut microbial fermentation of dietary fiber, promotes antiinflammatory Tregs and protects mice… read more here.
Keywords: promotes b10; cells antiinflammatory; gut derived; derived acetate ... See more keywords