Hit-to-Lead Optimization of Acetazolamide-Based Bacterial Carbonic Anhydrase Inhibitors with Efficacy In Vivo for Treatment of Vancomycin-Resistant Enterococci Septicemia
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DOI: 10.1021/acs.jmedchem.5c01584
Abstract: As one of the leading causes of hospital-acquired infections reported by the National Healthcare Safety Network, vancomycin-resistant enterococci (VRE) continue to afflict patients in healthcare facilities, with limited FDA-approved drugs available for treating systemic infections.… read more here.
Keywords: hit lead; acetazolamide based; resistant enterococci; carbonic anhydrase ... See more keywords