Acetoacetate protects macrophages from lactic acidosis-induced mitochondrial dysfunction by metabolic reprograming
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DOI: 10.1038/s41467-021-27426-x
Abstract: Lactic acidosis, the extracellular accumulation of lactate and protons, is a consequence of increased glycolysis triggered by insufficient oxygen supply to tissues. Macrophages are able to differentiate from monocytes under such acidotic conditions, and remain… read more here.
Keywords: acidosis induced; acetoacetate protects; protects macrophages; metabolic ... See more keywords