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   Articles with "acetohydroxyacid synthase" as a keyword



The 138th residue of acetohydroxyacid synthase in Corynebacterium glutamicum is important for the substrate binding specificity.

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recommendations! Published in 2019 at "Enzyme and microbial technology"

DOI: 10.1016/j.enzmictec.2019.06.001

Abstract: Corynebacterium glutamicum acetohydroxyacid synthase (AHAS), composed of two subunits IlvB and IlvN, catalyzes the first reaction in the biosynthetic pathway of branched-chain amino acids. It either condenses two pyruvates to yield acetolactate, leading to the… read more here.

Keywords: valine; acetohydroxyacid synthase; glutamicum; corynebacterium glutamicum ... See more keywords
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Design, synthesis and biological evaluation of novel N-nitrophenyl derivatives based on the structure of acetohydroxyacid synthase.

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recommendations! Published in 2018 at "Pesticide biochemistry and physiology"

DOI: 10.1016/j.pestbp.2018.01.011

Abstract: Acetohydroxyacid synthase (AHAS, EC: 2.2.1.6) is a target for the development of novel herbicides. Two series of N-nitrophenyl derivatives, type-A and type-B, were designed and synthesized based on the active site of the AHAS structure.… read more here.

Keywords: acetohydroxyacid synthase; nitrophenyl derivatives; ahas enzyme; structure ... See more keywords
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Crystal Structure of the Commercial Herbicide, Amidosulfuron, in Complex with Arabidopsis thaliana Acetohydroxyacid Synthase.

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recommendations! Published in 2023 at "Journal of agricultural and food chemistry"

DOI: 10.1021/acs.jafc.2c08528

Abstract: Amidosulfuron (AS) is from the commercial sulfonylurea herbicide family. It is highly effective against dicot broad-leaf weeds. This herbicide targets acetohydroxyacid synthase (AHAS), the first enzyme in the branched chain amino acid biosynthesis pathway. Here,… read more here.

Keywords: arabidopsis thaliana; acetohydroxyacid synthase; crystal structure;
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Herbicides that target acetohydroxyacid synthase are potent inhibitors of the growth of drug resistant Candida auris.

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recommendations! Published in 2020 at "ACS infectious diseases"

DOI: 10.1021/acsinfecdis.0c00229

Abstract: Acetohydroxyacid synthase (AHAS, EC 2.2.1.6) is the first enzyme in the branched chain amino acid biosynthesis pathway, is the target for more than 50 commercially available herbicides and is a promising target for antimicrobial drug… read more here.

Keywords: drug; candida auris; acetohydroxyacid synthase;

Resistance mutations of Pro197, Asp376 and Trp574 in the acetohydroxyacid synthase (AHAS) affect pigments, growths, and competitiveness of Descurainia sophia L

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recommendations! Published in 2017 at "Scientific Reports"

DOI: 10.1038/s41598-017-16655-0

Abstract: D. Sophia is one of the most problematic weed species infesting winter wheat in China, and has evolved high resistance to tribenuron-methyl. Amino acid substitutions at site of Pro197, Asp376 and Trp574 in acetohydroxyacid synthase… read more here.

Keywords: acetohydroxyacid synthase; pro197 asp376; trp574 acetohydroxyacid; resistance ... See more keywords
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Triazolopyrimidine herbicides are potent inhibitors of Aspergillus fumigatus acetohydroxyacid synthase and potential antifungal drug leads.

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recommendations! Published in 2021 at "Scientific reports"

DOI: 10.1038/s41598-021-00349-9

Abstract: Aspergillus fumigatus is a fungal pathogen whose effects can be debilitating and potentially fatal in immunocompromised patients. Current drug treatment options for this infectious disease are limited to just a few choices (e.g. voriconazole and… read more here.

Keywords: aspergillus fumigatus; acetohydroxyacid synthase; drug; antifungal drug ... See more keywords

Genetic origin and expression patterns of acetohydroxyacid synthase multigene family in Brassica juncea and B. carinata and their progenitors.

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recommendations! Published in 2022 at "Physiologia plantarum"

DOI: 10.1111/ppl.13669

Abstract: Acetohydroxyacid synthase (AHAS), the key enzyme in the branched-chain amino acids leucine, isoleucine, and valine biosynthesis pathway, has gained intensive investigation because it is the target of five different AHAS herbicides widely used to control… read more here.

Keywords: acetohydroxyacid synthase; juncea; brassica juncea; juncea carinata ... See more keywords